Reactome | IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol

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IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol Show undefined attributes

authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:169682] ligand-gated calcium channel activity of ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:169684] Jassal, Bijay, 2005-11-30
crossReference	[DatabaseIdentifier:12667421] RHEA:29671 [DatabaseIdentifier:9966344] RHEA:29672
dbId	169683
displayName	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-5607763] CLEC7A (Dectin-1) induces NFAT activation - Homo sapiens [Pathway:R-HSA-1489509] DAG and IP3 signaling - Homo sapiens [Pathway:R-HSA-112043] PLC beta mediated events - Homo sapiens [Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation - Homo sapiens [Pathway:R-HSA-2871809] FCERI mediated Ca+2 mobilization - Homo sapiens [Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens [Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens [Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis - Homo sapiens [Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent	[Pathway:R-HSA-111996] Ca-dependent events - Homo sapiens [Reaction:R-HSA-1168376] STIM1 oligomerizes - Homo sapiens [BlackBoxEvent:R-HSA-265166] Exocytosis of Insulin - Homo sapiens [Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine - Homo sapiens [Reaction:R-HSA-5218813] DAG and Ca+2 bind to PKC and tether it to membrane - Homo sapiens [Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
inferredFrom	[Reaction:R-RNO-182097] Calcium release from intracellular stores by IP3 receptor activation - Rattus norvegicus
input	[SimpleEntity:R-ALL-111875] Ca2+ [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9966345] Stephan, Ralf, 2025-09-19
name	IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol Release of calcium from intracellular stores by IP3 receptor activation
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
precedingEvent	[Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - Homo sapiens [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-111886] Positive regulation by 'I(1,4,5)P3 [cytosol]' [NegativeRegulation:R-HSA-5674039] Negative regulation by 'AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]'
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-169683
summation	[Summation:189821] IP3 promotes the release of intracellular calcium.
updateTrackers	[UpdateTracker:9785106] Update Tracker - [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - v52:[addRegulator] [UpdateTracker:9790362] Update Tracker - [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - v33:[addRegulator] [UpdateTracker:9791539] Update Tracker - [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - v29:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785106] Update Tracker - [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - v52:[addRegulator] [UpdateTracker:9790362] Update Tracker - [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - v33:[addRegulator] [UpdateTracker:9791539] Update Tracker - [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - v29:[modifyText]
(hasEvent)	[Pathway:R-HSA-5578775] Ion homeostasis [Pathway:R-HSA-422356] Regulation of insulin secretion [Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis [Pathway:R-HSA-5607763] CLEC7A (Dectin-1) induces NFAT activation [Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation [Pathway:R-HSA-2871809] FCERI mediated Ca+2 mobilization [Pathway:R-HSA-112043] PLC beta mediated events [Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Pathway:R-HSA-1489509] DAG and IP3 signaling [Pathway:R-HSA-2029485] Role of phospholipids in phagocytosis
(precedingEvent)	[BlackBoxEvent:R-HSA-265166] Exocytosis of Insulin [Pathway:R-HSA-111996] Ca-dependent events [Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine [Reaction:R-HSA-5218813] DAG and Ca+2 bind to PKC and tether it to membrane [Reaction:R-HSA-1168376] STIM1 oligomerizes [Reaction:R-HSA-74448] Calcium binds calmodulin
(inferredTo)	[Reaction:R-RNO-182097] Calcium release from intracellular stores by IP3 receptor activation

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