Reactome | Ion homeostasis

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Ion homeostasis Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728924
displayName	Ion homeostasis
eventOf	[Pathway:R-XTR-5576891] Cardiac conduction - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5673483] regulation of cardiac conduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-425661] SLC8A1,2,3 exchange 3Na+ for Ca2+ - Xenopus tropicalis [Reaction:R-XTR-5578777] DMPK phosphorylates PLN - Xenopus tropicalis [Reaction:R-XTR-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Xenopus tropicalis [Reaction:R-XTR-936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - Xenopus tropicalis [Reaction:R-XTR-9684068] ATP1A:ATP1B:FXYD binds cardiac glycosides - Xenopus tropicalis [Reaction:R-XTR-2089943] TRPC1 translocates calcium from the extracellular region to the cytosol - Xenopus tropicalis [Reaction:R-XTR-139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol - Xenopus tropicalis [Reaction:R-XTR-418309] ATP2B1-4 transport cytosolic Ca2+ to extracellular region - Xenopus tropicalis [Reaction:R-XTR-5617182] PRKACA phosphorylates PLN - Xenopus tropicalis [Reaction:R-XTR-5617179] PRKACA phosphorylates TNNI3 - Xenopus tropicalis [Reaction:R-XTR-5678261] KCNJ11:ABCC9 transports K+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-XTR-9691566] KCNJ11:ABCC9 binds nicorandil - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Ion homeostasis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5578775
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5576891] Cardiac conduction
(inferredTo)	[Pathway:R-HSA-5578775] Ion homeostasis

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