Reactome | CRAC translocates calcium from the extracellular region to the cytosol

Schema > Reaction > Entries

CRAC translocates calcium from the extracellular region to the cytosol Show undefined attributes

authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
catalystActivity	[CatalystActivity:434796] store-operated calcium channel activity of CRAC channel [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:434799] Jupe, S, 2009-09-02
crossReference	[DatabaseIdentifier:12667421] RHEA:29671
dbId	434798
displayName	CRAC translocates calcium from the extracellular region to the cytosol
edited	[InstanceEdit:870305] Jupe, S, 2010-06-07
eventOf	[Pathway:R-HSA-139853] Elevation of cytosolic Ca2+ levels - Homo sapiens [Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens [Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent	[Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine - Homo sapiens [Reaction:R-HSA-2025890] Calcineurin binds NFATC1,2,3 - Homo sapiens [Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
inferredFrom	[Reaction:R-DME-434802] Calcium influx via CRAC - Drosophila melanogaster
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CRAC translocates calcium from the extracellular region to the cytosol Calcium influx via CRAC
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
precedingEvent	[Reaction:R-HSA-434700] STIM1 activation of CRAC - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-434798
summation	[Summation:434800] Activation of Calcium-release-activated (CRAC) channels allo...

Referrals

(hasEvent)	[Pathway:R-HSA-5578775] Ion homeostasis [Pathway:R-HSA-139853] Elevation of cytosolic Ca2+ levels [Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine [Reaction:R-HSA-2025890] Calcineurin binds NFATC1,2,3 [Reaction:R-HSA-74448] Calcium binds calmodulin
(inferredTo)	[Reaction:R-DME-434802] Calcium influx via CRAC

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