Reactome | ATP2A1-3 transport Ca2+ from cytosol to ER lumen

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ATP2A1-3 transport Ca2+ from cytosol to ER lumen Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:418313] P-type calcium transporter activity of ATP2A1-3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:427908] Jupe, S, 2009-06-30
crossReference	[DatabaseIdentifier:12668224] RHEA:71799
dbId	427910
displayName	ATP2A1-3 transport Ca2+ from cytosol to ER lumen
edited	[InstanceEdit:1063531] Jupe, S, 2010-11-25
eventOf	[Pathway:R-HSA-5578775] Ion homeostasis - Homo sapiens [Pathway:R-HSA-936837] Ion transport by P-type ATPases - Homo sapiens
input	2 × [SimpleEntity:R-ALL-74016] Ca2+ [cytosol] 2 × [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:427922] Ca2+-activated ATPase in microsomes from human liver [LiteratureReference:427914] Localization and identification of Ca2+ATPases in highly purified human platelet plasma and intracellular membranes. Evidence that the monoclonal antibody PL/IM 430 recognizes the SERCA 3 Ca2+ATPase in human platelets [LiteratureReference:6809086] Sarco(endo)plasmic reticulum calcium ATPase (SERCA) inhibition by sarcolipin is encoded in its luminal tail [LiteratureReference:6809088] Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase [LiteratureReference:6809080] Sorcin interacts with sarcoplasmic reticulum Ca(2+)-ATPase and modulates excitation-contraction coupling in the heart
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ATP2A1-3 transport Ca2+ from cytosol to ER lumen Sequestration of Ca2+ to intracellular stores
orthologousEvent	[Reaction:R-PFA-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Plasmodium falciparum [Reaction:R-CEL-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Caenorhabditis elegans [Reaction:R-DME-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Drosophila melanogaster [Reaction:R-GGA-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Gallus gallus [Reaction:R-XTR-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Xenopus tropicalis [Reaction:R-DRE-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Danio rerio [Reaction:R-SSC-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Sus scrofa [Reaction:R-BTA-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Bos taurus [Reaction:R-CFA-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Canis familiaris [Reaction:R-RNO-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Rattus norvegicus [Reaction:R-MMU-427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - Mus musculus
output	2 × [SimpleEntity:R-ALL-111875] Ca2+ [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-5578777] DMPK phosphorylates PLN - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5578834] Negative regulation by 'PLN pentamer [sarcoplasmic reticulum membrane]' [PositiveRegulation:R-HSA-5578840] Positive regulation by 'p-S16-PLN pentamer [sarcoplasmic reticulum membrane]' [NegativeRegulation:R-HSA-6809096] Negative regulation by 'SLN [sarcoplasmic reticulum membrane]' [PositiveRegulation:R-HSA-6809098] Positive regulation by 'CAMK2 heteromer:CALM:4xCa2+ [plasma membrane]' [PositiveRegulation:R-HSA-6809100] Positive regulation by 'SRI [sarcoplasmic reticulum membrane]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1014332] He, Lei, 2010-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-427910
summation	[Summation:427921] Intracellular pools of Ca2+ serve as the source for inositol...
updateTrackers	[UpdateTracker:9787842] Update Tracker - [Reaction:427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - v44:[modifyText] [UpdateTracker:9783862] Update Tracker - [Reaction:427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - v55:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9786347] Update Tracker - [Reaction:427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - v50:[addRegulator]

Referrals

(updatedInstance)

[UpdateTracker:9787842] Update Tracker - [Reaction:427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - v44:[modifyText]
[UpdateTracker:9783862] Update Tracker - [Reaction:427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - v55:[addLiteratureReference, addRegulator, modifyText]
[UpdateTracker:9786347] Update Tracker - [Reaction:427910] ATP2A1-3 transport Ca2+ from cytosol to ER lumen - v50:[addRegulator]

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