Reactome | SLC-mediated transport of organic cations

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SLC-mediated transport of organic cations Show undefined attributes

authored	[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
created	[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
dbId	549127
deleted	[Deleted:9608154] Deletion of instance: 425374 [Deleted:9960232] Deletion of instance: 425393
diseasePathways	[Pathway:R-HSA-5619066] Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) - Homo sapiens [Pathway:R-HSA-5619053] Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) - Homo sapiens
displayName	SLC-mediated transport of organic cations
edited	[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
eventOf	[Pathway:R-HSA-425407] SLC-mediated transmembrane transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22794] amine transport
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-549129] OCT1 transports organic cations into hepatic cells - Homo sapiens [Reaction:R-HSA-549322] OCT1 transports organic cations out of hepatic cells - Homo sapiens [Reaction:R-HSA-549279] OCT2 mediates tubular uptake of organic cations in the kidney - Homo sapiens [Reaction:R-HSA-561054] OCT2 mediates tubular secretion of organic cations in the kidney - Homo sapiens [Reaction:R-HSA-549304] OCT3 mediates renal clearance of organic cations - Homo sapiens [Reaction:R-HSA-561072] OCT3 mediates renal uptake of organic cations - Homo sapiens [Reaction:R-HSA-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-549297] SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-597628] SLC22A18 exchanges extracellular organic cations for cytosolic H+ - Homo sapiens [Reaction:R-HSA-434650] MATEs mediate extrusion of xenobiotics - Homo sapiens [Reaction:R-HSA-444126] HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively - Homo sapiens [Reaction:R-HSA-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[LiteratureReference:549128] The SLC22 drug transporter family [LiteratureReference:444117] Cloning and functional expression of a urea transporter from human bone marrow cells
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC-mediated transport of organic cations Organic cation transport
orthologousEvent	[Pathway:R-MMU-549127] SLC-mediated transport of organic cations - Mus musculus [Pathway:R-RNO-549127] SLC-mediated transport of organic cations - Rattus norvegicus [Pathway:R-CFA-549127] SLC-mediated transport of organic cations - Canis familiaris [Pathway:R-BTA-549127] SLC-mediated transport of organic cations - Bos taurus [Pathway:R-SSC-549127] SLC-mediated transport of organic cations - Sus scrofa [Pathway:R-DRE-549127] SLC-mediated transport of organic cations - Danio rerio [Pathway:R-XTR-549127] SLC-mediated transport of organic cations - Xenopus tropicalis [Pathway:R-GGA-549127] SLC-mediated transport of organic cations - Gallus gallus [Pathway:R-DME-549127] SLC-mediated transport of organic cations - Drosophila melanogaster [Pathway:R-CEL-549127] SLC-mediated transport of organic cations - Caenorhabditis elegans [Pathway:R-DDI-549127] SLC-mediated transport of organic cations - Dictyostelium discoideum [Pathway:R-SPO-549127] SLC-mediated transport of organic cations - Schizosaccharomyces pombe [Pathway:R-SCE-549127] SLC-mediated transport of organic cations - Saccharomyces cerevisiae [Pathway:R-PFA-549127] SLC-mediated transport of organic cations - Plasmodium falciparum
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:706449] He, L, 2010-05-10 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-549127
summation	[Summation:549125] The organic cation transporters comprise three SLC22 members...
updateTrackers	[UpdateTracker:9782934] Update Tracker - [Pathway:549127] Organic cation transport - v58:[updateContainedRLE] [UpdateTracker:9785849] Update Tracker - [Pathway:549127] Organic cation transport - v51:[updateContainedRLE] [UpdateTracker:9785112] Update Tracker - [Pathway:549127] Organic cation transport - v52:[updateContainedRLE] [UpdateTracker:9964735] Update Tracker - [Pathway:549127] SLC-mediated transport of organic cations - v94:[removeHasEvent, removeLiteratureReference] [UpdateTracker:9787792] Update Tracker - [Pathway:549127] Organic cation transport - v44:[updateContainedRLE] [UpdateTracker:9781787] Update Tracker - [Pathway:549127] Organic cation transport - v60:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-425407] SLC-mediated transmembrane transport
(normalPathway)	[Pathway:R-HSA-5619066] Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) [Pathway:R-HSA-5619053] Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
(replacementInstances)	[Deleted:9608154] Deletion of instance: 425374 [Deleted:9960232] Deletion of instance: 425393
(updatedInstance)	[UpdateTracker:9782934] Update Tracker - [Pathway:549127] Organic cation transport - v58:[updateContainedRLE] [UpdateTracker:9785849] Update Tracker - [Pathway:549127] Organic cation transport - v51:[updateContainedRLE] [UpdateTracker:9785112] Update Tracker - [Pathway:549127] Organic cation transport - v52:[updateContainedRLE] [UpdateTracker:9964735] Update Tracker - [Pathway:549127] SLC-mediated transport of organic cations - v94:[removeHasEvent, removeLiteratureReference] [UpdateTracker:9787792] Update Tracker - [Pathway:549127] Organic cation transport - v44:[updateContainedRLE] [UpdateTracker:9781787] Update Tracker - [Pathway:549127] Organic cation transport - v60:[updateContainedRLE]

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