Reactome | SLC-mediated transport of organic cations

SLC-mediated transport of organic cations

Stable Identifier

R-HSA-549127

Type

Pathway

Species

Homo sapiens

Synonyms

Organic cation transport

ReviewStatus

5/5

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SLC-mediated transport of organic cations

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The organic cation transporters comprise three SLC22 members, OCT1-3. They can transport a wide range of organic cations including weak bases. All transport by OCTs is electrogenic, sodium-independent and bidirectional. Two further organic cation transporters mediate transport of ergothioneine and carnitine (Koepsell H and Endou H, 2004).

Literature References

PubMed ID	Title	Journal	Year
12883891	The SLC22 drug transporter family Koepsell, H, Endou, H	Pflugers Arch	2004
7989337	Cloning and functional expression of a urea transporter from human bone marrow cells Olives, B, Neau, P, Bailly, P, Hediger, MA, Rousselet, G, Cartron, JP, Ripoche, P	J Biol Chem	1994