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Organic cation transport
Stable Identifier
R-HSA-549127
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
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The organic cation transporters comprise three SLC22 members, OCT1-3. They can transport a wide range of organic cations including weak bases. All transport by OCTs is electrogenic, sodium-independent and bidirectional. Two further organic cation transporters mediate transport of ergothioneine and carnitine (Koepsell H and Endou H, 2004).
Literature References
PubMed ID
Title
Journal
Year
12883891
The SLC22 drug transporter family
Koepsell, H
,
Endou, H
Pflugers Arch
2004
Participants
Events
OCT1 transports organic cations into hepatic cells
(Homo sapiens)
OCT1 transports organic cations out of hepatic cells
(Homo sapiens)
OCT2 mediates tubular uptake of organic cations in the kidney
(Homo sapiens)
OCT2 mediates tubular secretion of organic cations in the kidney
(Homo sapiens)
OCT3 mediates renal clearance of organic cations
(Homo sapiens)
OCT3 mediates renal uptake of organic cations
(Homo sapiens)
SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
(Homo sapiens)
SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol
(Homo sapiens)
SLC22A18 exchanges extracellular organic cations for cytosolic H+
(Homo sapiens)
Participates
as an event of
Organic cation/anion/zwitterion transport (Homo sapiens)
Orthologous Events
Organic cation transport (Bos taurus)
Organic cation transport (Caenorhabditis elegans)
Organic cation transport (Canis familiaris)
Organic cation transport (Danio rerio)
Organic cation transport (Drosophila melanogaster)
Organic cation transport (Gallus gallus)
Organic cation transport (Mus musculus)
Organic cation transport (Plasmodium falciparum)
Organic cation transport (Rattus norvegicus)
Organic cation transport (Sus scrofa)
Organic cation transport (Xenopus tropicalis)
Authored
Jassal, B (2010-03-17)
Reviewed
He, L (2010-05-10)
Created
Jassal, B (2010-03-17)
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