Reactome | SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol

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SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
catalystActivity	[CatalystActivity:549225] secondary active transmembrane transporter activity of SLC22A4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
crossReference	[DatabaseIdentifier:12668214] RHEA:75843 [DatabaseIdentifier:9958566] RHEA:75844
dbId	549241
displayName	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
edited	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
eventOf	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations - Homo sapiens
input	[SimpleEntity:R-ALL-549261] ERGT [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:549265] Discovery of the ergothioneine transporter [LiteratureReference:5625678] An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis [LiteratureReference:5625677] SLC22A4 and RUNX1: identification of RA susceptible genes
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
orthologousEvent	[Reaction:R-CEL-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Bos taurus [Reaction:R-RNO-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-549260] ERGT [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
regulatedBy	[NegativeRegulation:R-HSA-5669078] Negative regulation by 'RUNX1 [plasma membrane]'
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-549241
summation	[Summation:549293] The human gene SLC22A4 encodes the ergothioneine transporter...
updateTrackers	[UpdateTracker:9785079] Update Tracker - [Reaction:549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - v52:[addRegulator, modifyText] [UpdateTracker:9785876] Update Tracker - [Reaction:549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - v51:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785079] Update Tracker - [Reaction:549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - v52:[addRegulator, modifyText] [UpdateTracker:9785876] Update Tracker - [Reaction:549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - v51:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations

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