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Schema
>
Reaction
>
Entries
OCT1 transports organic cations into hepatic cells
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authored
[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
catalystActivity
[CatalystActivity:549130] transmembrane transporter activity of OCT1 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
crossReference
[DatabaseIdentifier:9958541] RHEA:73860
[DatabaseIdentifier:9958531] RHEA:73864
[DatabaseIdentifier:9958540] RHEA:73876
[DatabaseIdentifier:9958532] RHEA:73884
[DatabaseIdentifier:9958534] RHEA:73880
[DatabaseIdentifier:9958536] RHEA:35041
[DatabaseIdentifier:9958547] RHEA:32752
dbId
549129
displayName
OCT1 transports organic cations into hepatic cells
edited
[InstanceEdit:549124] Jassal, Bijay, 2010-03-17
eventOf
[Pathway:R-HSA-549127] SLC-mediated transport of organic cations - Homo sapiens
input
[DefinedSet:R-ALL-549264] OCT1 substrates [extracellular region]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:549318] Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)
[LiteratureReference:374923] Cloning and characterization of two human polyspecific organic cation transporters
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
OCT1 transports organic cations into hepatic cells
negativePrecedingEvent
[NegativePrecedingEvent:9963170] Futile Cycle: MATEs mediate extrusion of xenobiotics
[NegativePrecedingEvent:9963169] Futile Cycle: OCT1 transports organic cations out of hepatic cells
[NegativePrecedingEvent:9963190] Futile Cycle: OCT2 mediates tubular secretion of organic cations in the kidney
[NegativePrecedingEvent:9963182] Futile Cycle: OCT3 mediates renal clearance of organic cations
orthologousEvent
[Reaction:R-CEL-549129] OCT1 transports organic cations into hepatic cells - Caenorhabditis elegans
[Reaction:R-DME-549129] OCT1 transports organic cations into hepatic cells - Drosophila melanogaster
[Reaction:R-GGA-549129] OCT1 transports organic cations into hepatic cells - Gallus gallus
[Reaction:R-XTR-549129] OCT1 transports organic cations into hepatic cells - Xenopus tropicalis
[Reaction:R-DRE-549129] OCT1 transports organic cations into hepatic cells - Danio rerio
[Reaction:R-SSC-549129] OCT1 transports organic cations into hepatic cells - Sus scrofa
[Reaction:R-BTA-549129] OCT1 transports organic cations into hepatic cells - Bos taurus
[Reaction:R-CFA-549129] OCT1 transports organic cations into hepatic cells - Canis familiaris
[Reaction:R-RNO-549129] OCT1 transports organic cations into hepatic cells - Rattus norvegicus
[Reaction:R-MMU-549129] OCT1 transports organic cations into hepatic cells - Mus musculus
output
[DefinedSet:R-ALL-549250] OCT1 substrates [cytosol]
releaseDate
2010-06-15
reverseReaction
[Reaction:R-HSA-549322] OCT1 transports organic cations out of hepatic cells
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:706449] He, L, 2010-05-10
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-549129
summation
[Summation:549315] The human gene SLC22A1 expresses the organic cation transpor...
updateTrackers
[UpdateTracker:9787635] Update Tracker - [Reaction:549129] OCT1 transports organic cations into hepatic cells - v44:[add_removeLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9787635] Update Tracker - [Reaction:549129] OCT1 transports organic cations into hepatic cells - v44:[add_removeLiteratureReference]
(hasEvent)
[Pathway:R-HSA-549127] SLC-mediated transport of organic cations
(precedingEvent)
[NegativePrecedingEvent:9963164] Futile Cycle: OCT1 transports organic cations into hepatic cells
[NegativePrecedingEvent:9963166] Futile Cycle: OCT1 transports organic cations into hepatic cells
[NegativePrecedingEvent:9963179] Futile Cycle: OCT1 transports organic cations into hepatic cells
[NegativePrecedingEvent:9963184] Futile Cycle: OCT1 transports organic cations into hepatic cells
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