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Entries
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
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authored
[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
created
[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
crossReference
[DatabaseIdentifier:12020755] Mondo:0008903
dbId
5619066
disease
[Disease:1500699] lung cancer
[Disease:1614291] rhabdomyosarcoma
displayName
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
edited
[InstanceEdit:5619074] Jassal, Bijay, 2014-08-22
eventOf
[Pathway:R-HSA-5619102] SLC transporter disorders - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[FailedReaction:R-HSA-5625574] Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2019-03-25
literatureReference
[LiteratureReference:5625566] Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain
[LiteratureReference:5625587] Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5
[LiteratureReference:597602] Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples
maxDepth
2
modified
[InstanceEdit:9958523] Stephan, Ralf, 2025-06-22
name
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)
normalPathway
[Pathway:R-HSA-549127] SLC-mediated transport of organic cations
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5619066
summation
[Summation:5625589] The human gene SLC22A18 (aka TSSC5) encodes organic cation t...
updateTrackers
[UpdateTracker:9778425] Update Tracker - [Pathway:5619066] Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) - v68:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9778425] Update Tracker - [Pathway:5619066] Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) - v68:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-5619102] SLC transporter disorders
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