Reactome | SLC-mediated transport of organic cations

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SLC-mediated transport of organic cations Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223835
displayName	SLC-mediated transport of organic cations
eventOf	[Pathway:R-RNO-425407] SLC-mediated transmembrane transport - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:22794] amine transport
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-549129] OCT1 transports organic cations into hepatic cells - Rattus norvegicus [Reaction:R-RNO-549322] OCT1 transports organic cations out of hepatic cells - Rattus norvegicus [Reaction:R-RNO-549279] OCT2 mediates tubular uptake of organic cations in the kidney - Rattus norvegicus [Reaction:R-RNO-561054] OCT2 mediates tubular secretion of organic cations in the kidney - Rattus norvegicus [Reaction:R-RNO-549304] OCT3 mediates renal clearance of organic cations - Rattus norvegicus [Reaction:R-RNO-561072] OCT3 mediates renal uptake of organic cations - Rattus norvegicus [Reaction:R-RNO-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-RNO-549297] SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-RNO-597628] SLC22A18 exchanges extracellular organic cations for cytosolic H+ - Rattus norvegicus [Reaction:R-RNO-434650] MATEs mediate extrusion of xenobiotics - Rattus norvegicus [Reaction:R-RNO-444126] HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively - Rattus norvegicus [Reaction:R-RNO-8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SLC-mediated transport of organic cations Organic cation transport
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-549127
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-425407] SLC-mediated transmembrane transport
(inferredTo)	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations

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