Reactome | OCT3 mediates renal uptake of organic cations

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OCT3 mediates renal uptake of organic cations Show undefined attributes

authored	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
catalystActivity	[CatalystActivity:549240] transmembrane transporter activity of SLC22A3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
crossReference	[DatabaseIdentifier:9958530] RHEA:73885
dbId	561072
displayName	OCT3 mediates renal uptake of organic cations
edited	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
eventOf	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations - Homo sapiens
input	[DefinedSet:R-ALL-549255] OCT3 substrates [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:549283] Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter [LiteratureReference:549238] Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	OCT3 mediates renal uptake of organic cations
negativePrecedingEvent	[NegativePrecedingEvent:9963180] Futile Cycle: MATEs mediate extrusion of xenobiotics [NegativePrecedingEvent:9963174] Futile Cycle: OCT1 transports organic cations out of hepatic cells [NegativePrecedingEvent:9963178] Futile Cycle: OCT2 mediates tubular secretion of organic cations in the kidney [NegativePrecedingEvent:9963181] Futile Cycle: OCT3 mediates renal clearance of organic cations
orthologousEvent	[Reaction:R-CEL-561072] OCT3 mediates renal uptake of organic cations - Caenorhabditis elegans [Reaction:R-DME-561072] OCT3 mediates renal uptake of organic cations - Drosophila melanogaster [Reaction:R-GGA-561072] OCT3 mediates renal uptake of organic cations - Gallus gallus [Reaction:R-XTR-561072] OCT3 mediates renal uptake of organic cations - Xenopus tropicalis [Reaction:R-DRE-561072] OCT3 mediates renal uptake of organic cations - Danio rerio [Reaction:R-SSC-561072] OCT3 mediates renal uptake of organic cations - Sus scrofa [Reaction:R-BTA-561072] OCT3 mediates renal uptake of organic cations - Bos taurus [Reaction:R-CFA-561072] OCT3 mediates renal uptake of organic cations - Canis familiaris [Reaction:R-RNO-561072] OCT3 mediates renal uptake of organic cations - Rattus norvegicus [Reaction:R-MMU-561072] OCT3 mediates renal uptake of organic cations - Mus musculus
output	[DefinedSet:R-ALL-549326] OCT3 substrates [cytosol]
releaseDate	2010-06-15
reverseReaction	[Reaction:R-HSA-549304] OCT3 mediates renal clearance of organic cations
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-561072
summation	[Summation:549232] The human gene SLC22A3 encodes organic cation transporter OC...

Referrals

(hasEvent)	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations
(precedingEvent)	[NegativePrecedingEvent:9963175] Futile Cycle: OCT3 mediates renal uptake of organic cations [NegativePrecedingEvent:9963191] Futile Cycle: OCT3 mediates renal uptake of organic cations [NegativePrecedingEvent:9963176] Futile Cycle: OCT3 mediates renal uptake of organic cations [NegativePrecedingEvent:9963185] Futile Cycle: OCT3 mediates renal uptake of organic cations