Reactome | MATEs mediate extrusion of xenobiotics

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MATEs mediate extrusion of xenobiotics Show undefined attributes

authored	[InstanceEdit:434666] Jassal, Bijay, 2009-09-02
catalystActivity	[CatalystActivity:446610] transmembrane transporter activity of MATE1/2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:434666] Jassal, Bijay, 2009-09-02
crossReference	[DatabaseIdentifier:9958564] RHEA:72184
dbId	434650
displayName	MATEs mediate extrusion of xenobiotics
edited	[InstanceEdit:433105] Jassal, Bijay, 2009-08-21
eventOf	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-ALL-446589] MATE substrates [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434658] A human transporter protein that mediates the final excretion step for toxic organic cations [LiteratureReference:434644] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters [LiteratureReference:434640] Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MATEs mediate extrusion of xenobiotics
negativePrecedingEvent	[NegativePrecedingEvent:9963184] Futile Cycle: OCT1 transports organic cations into hepatic cells [NegativePrecedingEvent:9963188] Futile Cycle: OCT2 mediates tubular uptake of organic cations in the kidney [NegativePrecedingEvent:9963185] Futile Cycle: OCT3 mediates renal uptake of organic cations
orthologousEvent	[Reaction:R-PFA-434650] MATEs mediate extrusion of xenobiotics - Plasmodium falciparum [Reaction:R-SCE-434650] MATEs mediate extrusion of xenobiotics - Saccharomyces cerevisiae [Reaction:R-SPO-434650] MATEs mediate extrusion of xenobiotics - Schizosaccharomyces pombe [Reaction:R-DDI-434650] MATEs mediate extrusion of xenobiotics - Dictyostelium discoideum [Reaction:R-GGA-434650] MATEs mediate extrusion of xenobiotics - Gallus gallus [Reaction:R-XTR-434650] MATEs mediate extrusion of xenobiotics - Xenopus tropicalis [Reaction:R-DRE-434650] MATEs mediate extrusion of xenobiotics - Danio rerio [Reaction:R-SSC-434650] MATEs mediate extrusion of xenobiotics - Sus scrofa [Reaction:R-BTA-434650] MATEs mediate extrusion of xenobiotics - Bos taurus [Reaction:R-CFA-434650] MATEs mediate extrusion of xenobiotics - Canis familiaris [Reaction:R-RNO-434650] MATEs mediate extrusion of xenobiotics - Rattus norvegicus [Reaction:R-MMU-434650] MATEs mediate extrusion of xenobiotics - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-446597] MATE substrates [extracellular region]
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446289] He, Lei, 2009-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-434650
summation	[Summation:434653] The human gene family SLC47 encodes 2 multidrug and toxin ex...

Referrals

(hasEvent)	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations
(precedingEvent)	[NegativePrecedingEvent:9963180] Futile Cycle: MATEs mediate extrusion of xenobiotics [NegativePrecedingEvent:9963165] Futile Cycle: MATEs mediate extrusion of xenobiotics [NegativePrecedingEvent:9963170] Futile Cycle: MATEs mediate extrusion of xenobiotics

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