Reactome | OCT1 transports organic cations out of hepatic cells

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OCT1 transports organic cations out of hepatic cells Show undefined attributes

authored	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
catalystActivity	[CatalystActivity:549130] transmembrane transporter activity of OCT1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
crossReference	[DatabaseIdentifier:9958539] RHEA:35040 [DatabaseIdentifier:9958542] RHEA:73861 [DatabaseIdentifier:9958537] RHEA:73865 [DatabaseIdentifier:9958533] RHEA:73877 [DatabaseIdentifier:9958538] RHEA:73881 [DatabaseIdentifier:9958530] RHEA:73885 [DatabaseIdentifier:9958551] RHEA:32753
dbId	549322
displayName	OCT1 transports organic cations out of hepatic cells
edited	[InstanceEdit:549249] Jassal, Bijay, 2010-03-19
eventOf	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations - Homo sapiens
input	[DefinedSet:R-ALL-549250] OCT1 substrates [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:549318] Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa) [LiteratureReference:374923] Cloning and characterization of two human polyspecific organic cation transporters
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	OCT1 transports organic cations out of hepatic cells
negativePrecedingEvent	[NegativePrecedingEvent:9963179] Futile Cycle: OCT1 transports organic cations into hepatic cells [NegativePrecedingEvent:9963173] Futile Cycle: OCT2 mediates tubular uptake of organic cations in the kidney [NegativePrecedingEvent:9963176] Futile Cycle: OCT3 mediates renal uptake of organic cations
orthologousEvent	[Reaction:R-CEL-549322] OCT1 transports organic cations out of hepatic cells - Caenorhabditis elegans [Reaction:R-DME-549322] OCT1 transports organic cations out of hepatic cells - Drosophila melanogaster [Reaction:R-GGA-549322] OCT1 transports organic cations out of hepatic cells - Gallus gallus [Reaction:R-XTR-549322] OCT1 transports organic cations out of hepatic cells - Xenopus tropicalis [Reaction:R-DRE-549322] OCT1 transports organic cations out of hepatic cells - Danio rerio [Reaction:R-SSC-549322] OCT1 transports organic cations out of hepatic cells - Sus scrofa [Reaction:R-BTA-549322] OCT1 transports organic cations out of hepatic cells - Bos taurus [Reaction:R-CFA-549322] OCT1 transports organic cations out of hepatic cells - Canis familiaris [Reaction:R-RNO-549322] OCT1 transports organic cations out of hepatic cells - Rattus norvegicus [Reaction:R-MMU-549322] OCT1 transports organic cations out of hepatic cells - Mus musculus
output	[DefinedSet:R-ALL-549264] OCT1 substrates [extracellular region]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-549322
summation	[Summation:549315] The human gene SLC22A1 expresses the organic cation transpor...
updateTrackers	[UpdateTracker:9788064] Update Tracker - [Reaction:549322] OCT1 transports organic cations out of hepatic cells - v44:[add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9788064] Update Tracker - [Reaction:549322] OCT1 transports organic cations out of hepatic cells - v44:[add_removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-549127] SLC-mediated transport of organic cations
(precedingEvent)	[NegativePrecedingEvent:9963174] Futile Cycle: OCT1 transports organic cations out of hepatic cells [NegativePrecedingEvent:9963177] Futile Cycle: OCT1 transports organic cations out of hepatic cells [NegativePrecedingEvent:9963169] Futile Cycle: OCT1 transports organic cations out of hepatic cells
(reverseReaction)	[Reaction:R-HSA-549129] OCT1 transports organic cations into hepatic cells

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