Reactome | PINK1-PRKN Mediated Mitophagy

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PINK1-PRKN Mediated Mitophagy Show undefined attributes

authored	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5205680] Gillespie, Marc E, 2013-12-04
dbId	5205685
displayName	PINK1-PRKN Mediated Mitophagy
edited	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
eventOf	[Pathway:R-HSA-5205647] Mitophagy - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20607] macroautophagy
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Homo sapiens [Reaction:R-HSA-5205681] Pink1 is cleaved on healthy mitochondria - Homo sapiens [Reaction:R-HSA-5205672] Uncleaved Pink1 accumulates in damaged mitochondria - Homo sapiens [Reaction:R-HSA-9834076] PINK1 is autophosphorylated - Homo sapiens [Reaction:R-HSA-9834945] PINK1 phosphorylates Ub on MOM proteins - Homo sapiens [BlackBoxEvent:R-HSA-9835009] PRKN binds p-S-Ub:MOM proteins - Homo sapiens [Reaction:R-HSA-9835011] PINK1 phosphorylates PRKN at S65 - Homo sapiens [BlackBoxEvent:R-HSA-9834070] PRKN ubiquitinates MOM substrates - Homo sapiens [Reaction:R-HSA-5205673] p62 binds ubiquitinated mitochondrial substrates - Homo sapiens [Reaction:R-HSA-5205649] p62 links damaged mitochondria to LC3 - Homo sapiens [Reaction:R-HSA-5205663] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Homo sapiens [Reaction:R-HSA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Homo sapiens [Reaction:R-HSA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Homo sapiens [Reaction:R-HSA-9824897] p-S-TBK1 phosphorylates OPTN - Homo sapiens [Reaction:R-HSA-9824892] MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria - Homo sapiens [Reaction:R-HSA-9840807] OPTN binds ATG9A - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:5205687] Mechanisms of mitophagy
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PINK1-PRKN Mediated Mitophagy
orthologousEvent	[Pathway:R-MMU-5205685] PINK1-PRKN Mediated Mitophagy - Mus musculus [Pathway:R-RNO-5205685] PINK1-PRKN Mediated Mitophagy - Rattus norvegicus [Pathway:R-CFA-5205685] PINK1-PRKN Mediated Mitophagy - Canis familiaris [Pathway:R-BTA-5205685] PINK1-PRKN Mediated Mitophagy - Bos taurus [Pathway:R-SSC-5205685] PINK1-PRKN Mediated Mitophagy - Sus scrofa [Pathway:R-DRE-5205685] PINK1-PRKN Mediated Mitophagy - Danio rerio [Pathway:R-XTR-5205685] PINK1-PRKN Mediated Mitophagy - Xenopus tropicalis [Pathway:R-GGA-5205685] PINK1-PRKN Mediated Mitophagy - Gallus gallus [Pathway:R-DME-5205685] PINK1-PRKN Mediated Mitophagy - Drosophila melanogaster [Pathway:R-CEL-5205685] PINK1-PRKN Mediated Mitophagy - Caenorhabditis elegans [Pathway:R-SCE-5205685] PINK1-PRKN Mediated Mitophagy - Saccharomyces cerevisiae
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:6793554] Chauss, Daniel, Kantorow, Marc, 2015-09-01
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5205685
summation	[Summation:5205639] This is the process of selective removal of damaged mitochon...
updateTrackers	[UpdateTracker:9863971] Update Tracker - [Pathway:5205685] PINK1-PRKN Mediated Mitophagy - v88:[modifyText, updateContainedRLE] [UpdateTracker:9910948] Update Tracker - [Pathway:5205685] PINK1-PRKN Mediated Mitophagy - v89:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9778429] Update Tracker - [Pathway:5205685] PINK1-PRKN Mediated Mitophagy - v68:[updateContainedRLE] [UpdateTracker:9842284] Update Tracker - [Pathway:5205685] PINK1-PRKN Mediated Mitophagy - v86:[modifyText, updateContainedRLE]

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[Pathway:R-HSA-5205647] Mitophagy

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