Reactome | OPTN, TBK1 bind ubiquitinated MOM proteins

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OPTN, TBK1 bind ubiquitinated MOM proteins Show undefined attributes

authored	[InstanceEdit:9834059] Shamovsky, Veronica, 2023-05-05
category	binding
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:9824889] Shamovsky, Veronica, 2023-01-23
dbId	9824888
displayName	OPTN, TBK1 bind ubiquitinated MOM proteins
edited	[InstanceEdit:9907508] Shamovsky, Veronica, 2024-04-11
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Homo sapiens
input	[DefinedSet:R-HSA-9824893] K63polyUb-MOM proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-9687907] OPTN [cytosol] [EntityWithAccessionedSequence:R-HSA-166267] TBK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9840359] Orchestration of selective autophagy by cargo receptors [LiteratureReference:9838808] The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy [LiteratureReference:9840348] Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation [LiteratureReference:9907501] Optineurin provides a mitophagy contact site for TBK1 activation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	OPTN, TBK1 bind ubiquitinated MOM proteins
orthologousEvent	[Reaction:R-DME-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Drosophila melanogaster [Reaction:R-GGA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Gallus gallus [Reaction:R-XTR-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Xenopus tropicalis [Reaction:R-DRE-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Danio rerio [Reaction:R-SSC-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Sus scrofa [Reaction:R-BTA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Bos taurus [Reaction:R-CFA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Canis familiaris [Reaction:R-RNO-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Rattus norvegicus [Reaction:R-MMU-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Mus musculus
output	[Complex:R-HSA-9824896] TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9834070] PRKN ubiquitinates MOM substrates - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9824888
summation	[Summation:9840304] Damaged mitochondria are flagged by ubiquitin (Ub) chains th...

Referrals

(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy
(precedingEvent)	[Reaction:R-HSA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins