Reactome | PINK1 phosphorylates PRKN at S65

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PINK1 phosphorylates PRKN at S65 Show undefined attributes

authored	[InstanceEdit:9834059] Shamovsky, Veronica, 2023-05-05
catalystActivity	[CatalystActivity:9834937] protein serine/threonine kinase activity of p-S228,S402-PINK1:p-S228,S402-PINK1 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9834968] Shamovsky, Veronica, 2023-05-11
dbId	9835011
displayName	PINK1 phosphorylates PRKN at S65
edited	[InstanceEdit:9910572] Shamovsky, Veronica, 2024-05-15
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9835020] PRKN:Ub-MOM proteins [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9838797] Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy [LiteratureReference:9839881] Mechanism of parkin activation by PINK1 [LiteratureReference:9839902] Mechanism of parkin activation by phosphorylation [LiteratureReference:9838790] Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PINK1 phosphorylates PRKN at S65
orthologousEvent	[Reaction:R-CEL-9835011] PINK1 phosphorylates PRKN at S65 - Caenorhabditis elegans [Reaction:R-DME-9835011] PINK1 phosphorylates PRKN at S65 - Drosophila melanogaster [Reaction:R-DRE-9835011] PINK1 phosphorylates PRKN at S65 - Danio rerio [Reaction:R-BTA-9835011] PINK1 phosphorylates PRKN at S65 - Bos taurus [Reaction:R-CFA-9835011] PINK1 phosphorylates PRKN at S65 - Canis familiaris [Reaction:R-RNO-9835011] PINK1 phosphorylates PRKN at S65 - Rattus norvegicus [Reaction:R-MMU-9835011] PINK1 phosphorylates PRKN at S65 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9834950] p-S65-PRKN:Ub-MOM proteins [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-9834076] PINK1 is autophosphorylated - Homo sapiens [BlackBoxEvent:R-HSA-9835009] PRKN binds p-S-Ub:MOM proteins - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9835011
summation	[Summation:9839893] The E3 ubiquitin protein ligase parkin (PRKN) translocates t...

Referrals

(hasEvent)

[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy