Reactome | PINK1 is autophosphorylated

Schema > Reaction > Entries

PINK1 is autophosphorylated Show undefined attributes

authored	[InstanceEdit:9834059] Shamovsky, Veronica, 2023-05-05
catalystActivity	[CatalystActivity:9834062] protein serine/threonine kinase activity of PINK1 [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9834931] protein serine/threonine kinase activity of p-S228,S402-PINK1:p-S228,S402-PINK1 [mitochondrial outer membrane] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9834059] Shamovsky, Veronica, 2023-05-05
dbId	9834076
displayName	PINK1 is autophosphorylated
edited	[InstanceEdit:9910572] Shamovsky, Veronica, 2024-05-15
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-9835011] PINK1 phosphorylates PRKN at S65 - Homo sapiens [Reaction:R-HSA-9834945] PINK1 phosphorylates Ub on MOM proteins - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-5205653] PINK1 [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9834065] PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 [LiteratureReference:9834922] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PINK1 is autophosphorylated
orthologousEvent	[Reaction:R-CEL-9834076] PINK1 is autophosphorylated - Caenorhabditis elegans [Reaction:R-DME-9834076] PINK1 is autophosphorylated - Drosophila melanogaster [Reaction:R-GGA-9834076] PINK1 is autophosphorylated - Gallus gallus [Reaction:R-DRE-9834076] PINK1 is autophosphorylated - Danio rerio [Reaction:R-SSC-9834076] PINK1 is autophosphorylated - Sus scrofa [Reaction:R-BTA-9834076] PINK1 is autophosphorylated - Bos taurus [Reaction:R-CFA-9834076] PINK1 is autophosphorylated - Canis familiaris [Reaction:R-RNO-9834076] PINK1 is autophosphorylated - Rattus norvegicus [Reaction:R-MMU-9834076] PINK1 is autophosphorylated - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9834066] p-S228,S402-PINK1:p-S228,S402-PINK1 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-5205672] Uncleaved Pink1 accumulates in damaged mitochondria - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9834076
summation	[Summation:9834075] PTEN-induced putative kinase 1 (PINK1) is rapidly degraded i...

Referrals

(precedingEvent)	[Reaction:R-HSA-9835011] PINK1 phosphorylates PRKN at S65 [Reaction:R-HSA-9834945] PINK1 phosphorylates Ub on MOM proteins
(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy