Reactome | p62 links damaged mitochondria to LC3

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p62 links damaged mitochondria to LC3 Show undefined attributes

authored	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5205680] Gillespie, Marc E, 2013-12-04
dbId	5205649
displayName	p62 links damaged mitochondria to LC3
edited	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-5205663] LC3 binds the autophagosome membrane Atg5-Atg12 complex - Homo sapiens
input	[Complex:R-HSA-5205659] K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] [DefinedSet:R-HSA-5205658] LC3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5205644] Autophagosome formation and molecular mechanism of autophagy
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p62 links damaged mitochondria to LC3
orthologousEvent	[Reaction:R-CEL-5205649] p62 links damaged mitochondria to LC3 - Caenorhabditis elegans [Reaction:R-GGA-5205649] p62 links damaged mitochondria to LC3 - Gallus gallus [Reaction:R-XTR-5205649] p62 links damaged mitochondria to LC3 - Xenopus tropicalis [Reaction:R-DRE-5205649] p62 links damaged mitochondria to LC3 - Danio rerio [Reaction:R-SSC-5205649] p62 links damaged mitochondria to LC3 - Sus scrofa [Reaction:R-BTA-5205649] p62 links damaged mitochondria to LC3 - Bos taurus [Reaction:R-RNO-5205649] p62 links damaged mitochondria to LC3 - Rattus norvegicus [Reaction:R-MMU-5205649] p62 links damaged mitochondria to LC3 - Mus musculus
output	[Complex:R-HSA-5205670] LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol]
precedingEvent	[Reaction:R-HSA-5205673] p62 binds ubiquitinated mitochondrial substrates - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793554] Chauss, Daniel, Kantorow, Marc, 2015-09-01
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5205649
summation	[Summation:5205626] p62 links to the microtubule-associated protein Autophagy ma...
updateTrackers	[UpdateTracker:9864169] Update Tracker - [Reaction:5205649] p62 links damaged mitochondria to LC3 - v88:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864169] Update Tracker - [Reaction:5205649] p62 links damaged mitochondria to LC3 - v88:[modifyText]
(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy
(precedingEvent)	[Reaction:R-HSA-5205663] LC3 binds the autophagosome membrane Atg5-Atg12 complex