Reactome | p62 binds ubiquitinated mitochondrial substrates

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p62 binds ubiquitinated mitochondrial substrates Show undefined attributes

authored	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5205680] Gillespie, Marc E, 2013-12-04
dbId	5205673
displayName	p62 binds ubiquitinated mitochondrial substrates
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-5205649] p62 links damaged mitochondria to LC3 - Homo sapiens
input	[DefinedSet:R-HSA-9843326] K48polyUb-MOM proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-193937] SQSTM1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5205644] Autophagosome formation and molecular mechanism of autophagy
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p62 binds ubiquitinated mitochondrial substrates
orthologousEvent	[Reaction:R-CEL-5205673] p62 binds ubiquitinated mitochondrial substrates - Caenorhabditis elegans [Reaction:R-DME-5205673] p62 binds ubiquitinated mitochondrial substrates - Drosophila melanogaster [Reaction:R-GGA-5205673] p62 binds ubiquitinated mitochondrial substrates - Gallus gallus [Reaction:R-XTR-5205673] p62 binds ubiquitinated mitochondrial substrates - Xenopus tropicalis [Reaction:R-DRE-5205673] p62 binds ubiquitinated mitochondrial substrates - Danio rerio [Reaction:R-SSC-5205673] p62 binds ubiquitinated mitochondrial substrates - Sus scrofa [Reaction:R-BTA-5205673] p62 binds ubiquitinated mitochondrial substrates - Bos taurus [Reaction:R-CFA-5205673] p62 binds ubiquitinated mitochondrial substrates - Canis familiaris [Reaction:R-RNO-5205673] p62 binds ubiquitinated mitochondrial substrates - Rattus norvegicus [Reaction:R-MMU-5205673] p62 binds ubiquitinated mitochondrial substrates - Mus musculus
output	[Complex:R-HSA-5205659] K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9834070] PRKN ubiquitinates MOM substrates - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:6793554] Chauss, Daniel, Kantorow, Marc, 2015-09-01
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5205673
summation	[Summation:5205664] After the ubiquitination events, p62 is recruited to mitocho...
updateTrackers	[UpdateTracker:9864351] Update Tracker - [Reaction:5205673] p62 binds ubiquitinated mitochondrial substrates - v88:[modifyText] [UpdateTracker:9910993] Update Tracker - [Reaction:5205673] p62 binds ubiquitinated mitochondrial substrates - v89:[add_removeInput]

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(updatedInstance)	[UpdateTracker:9864351] Update Tracker - [Reaction:5205673] p62 binds ubiquitinated mitochondrial substrates - v88:[modifyText] [UpdateTracker:9910993] Update Tracker - [Reaction:5205673] p62 binds ubiquitinated mitochondrial substrates - v89:[add_removeInput]
(precedingEvent)	[Reaction:R-HSA-5205649] p62 links damaged mitochondria to LC3
(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy