Reactome | Pink1 is recruited from the cytoplasm to the mitochondria

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Pink1 is recruited from the cytoplasm to the mitochondria Show undefined attributes

authored	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
catalystActivity	[CatalystActivity:1268023] protein transmembrane transporter activity of TOMM40 Complex [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5205680] Gillespie, Marc E, 2013-12-04
dbId	5205661
displayName	Pink1 is recruited from the cytoplasm to the mitochondria
edited	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-5205681] Pink1 is cleaved on healthy mitochondria - Homo sapiens [Reaction:R-HSA-5205672] Uncleaved Pink1 accumulates in damaged mitochondria - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5205637] PINK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5205666] PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Pink1 is recruited from the cytoplasm to the mitochondria
orthologousEvent	[Reaction:R-GGA-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Gallus gallus [Reaction:R-DRE-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Danio rerio [Reaction:R-SSC-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Sus scrofa [Reaction:R-BTA-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Bos taurus [Reaction:R-CFA-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Canis familiaris [Reaction:R-RNO-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Rattus norvegicus [Reaction:R-MMU-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5205671] PINK1 [mitochondrial intermembrane space]
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793554] Chauss, Daniel, Kantorow, Marc, 2015-09-01
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5205661
summation	[Summation:5205646] PINK1 is constitutively synthesized and imported into all mi...

Referrals

(precedingEvent)	[Reaction:R-HSA-5205681] Pink1 is cleaved on healthy mitochondria [Reaction:R-HSA-5205672] Uncleaved Pink1 accumulates in damaged mitochondria
(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy

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