Reactome | PRKN binds p-S-Ub:MOM proteins

Schema > BlackBoxEvent > Entries

PRKN binds p-S-Ub:MOM proteins Show undefined attributes

authored	[InstanceEdit:9834059] Shamovsky, Veronica, 2023-05-05
category	omitted
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9834968] Shamovsky, Veronica, 2023-05-11
dbId	9835009
deleted	[Deleted:9910602] Deletion of instance: 5205652
displayName	PRKN binds p-S-Ub:MOM proteins
edited	[InstanceEdit:9910572] Shamovsky, Veronica, 2024-05-15
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9834070] PRKN ubiquitinates MOM substrates - Homo sapiens [Reaction:R-HSA-9835011] PINK1 phosphorylates PRKN at S65 - Homo sapiens
input	[CandidateSet:R-HSA-9834977] p-S65-Ub:MOM proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-201579] PRKN [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9838790] Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation [LiteratureReference:9838789] Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering [LiteratureReference:9838786] Ubiquitin is phosphorylated by PINK1 to activate parkin [LiteratureReference:9838775] Structural basis for feedforward control in the PINK1/Parkin pathway [LiteratureReference:9838797] Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy [LiteratureReference:9839449] PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity [LiteratureReference:9839454] Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis [LiteratureReference:9839453] Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65 [LiteratureReference:5205666] PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PRKN binds p-S-Ub:MOM proteins
orthologousEvent	[BlackBoxEvent:R-SCE-9835009] PRKN binds p-S-Ub:MOM proteins - Saccharomyces cerevisiae [BlackBoxEvent:R-CEL-9835009] PRKN binds p-S-Ub:MOM proteins - Caenorhabditis elegans [BlackBoxEvent:R-DME-9835009] PRKN binds p-S-Ub:MOM proteins - Drosophila melanogaster [BlackBoxEvent:R-DRE-9835009] PRKN binds p-S-Ub:MOM proteins - Danio rerio [BlackBoxEvent:R-BTA-9835009] PRKN binds p-S-Ub:MOM proteins - Bos taurus [BlackBoxEvent:R-CFA-9835009] PRKN binds p-S-Ub:MOM proteins - Canis familiaris [BlackBoxEvent:R-RNO-9835009] PRKN binds p-S-Ub:MOM proteins - Rattus norvegicus [BlackBoxEvent:R-MMU-9835009] PRKN binds p-S-Ub:MOM proteins - Mus musculus
output	[Complex:R-HSA-9835020] PRKN:Ub-MOM proteins [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-9834945] PINK1 phosphorylates Ub on MOM proteins - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9835009
summation	[Summation:9839455] A loss in mitochondrial membrane potential leads to the PINK...

Referrals

(replacementInstances)	[Deleted:9910602] Deletion of instance: 5205652
(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy
(precedingEvent)	[Reaction:R-HSA-9835011] PINK1 phosphorylates PRKN at S65 [BlackBoxEvent:R-HSA-9834070] PRKN ubiquitinates MOM substrates

Cite Us!