Reactome | TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins

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TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins Show undefined attributes

authored	[InstanceEdit:9834059] Shamovsky, Veronica, 2023-05-05
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9824889] Shamovsky, Veronica, 2023-01-23
dbId	9824894
displayName	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
edited	[InstanceEdit:9907508] Shamovsky, Veronica, 2024-04-11
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-9824897] p-S-TBK1 phosphorylates OPTN - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9824896] TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9838808] The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy [LiteratureReference:9827959] Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria [LiteratureReference:9907501] Optineurin provides a mitophagy contact site for TBK1 activation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
orthologousEvent	[Reaction:R-DME-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Drosophila melanogaster [Reaction:R-GGA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Gallus gallus [Reaction:R-XTR-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Xenopus tropicalis [Reaction:R-DRE-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Danio rerio [Reaction:R-SSC-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Sus scrofa [Reaction:R-BTA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Bos taurus [Reaction:R-CFA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Canis familiaris [Reaction:R-RNO-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Rattus norvegicus [Reaction:R-MMU-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9824891] p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9824894
summation	[Summation:9840615] Upon mitochondrial damage, TANK-binding kinase 1 (TBK1) is r...

Referrals

(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy
(precedingEvent)	[Reaction:R-HSA-9824897] p-S-TBK1 phosphorylates OPTN