Reactome | Pink1 is cleaved on healthy mitochondria

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Pink1 is cleaved on healthy mitochondria Show undefined attributes

authored	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:5205680] Gillespie, Marc E, 2013-12-04
dbId	5205681
displayName	Pink1 is cleaved on healthy mitochondria
edited	[InstanceEdit:5205669] Gillespie, ME, 2013-11-20
eventOf	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5205671] PINK1 [mitochondrial intermembrane space]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5205666] PINK1 is selectively stabilized on impaired mitochondria to activate Parkin [LiteratureReference:5205635] Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL [LiteratureReference:5205641] Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Pink1 is cleaved on healthy mitochondria
orthologousEvent	[Reaction:R-CEL-5205681] Pink1 is cleaved on healthy mitochondria - Caenorhabditis elegans [Reaction:R-DME-5205681] Pink1 is cleaved on healthy mitochondria - Drosophila melanogaster [Reaction:R-GGA-5205681] Pink1 is cleaved on healthy mitochondria - Gallus gallus [Reaction:R-DRE-5205681] Pink1 is cleaved on healthy mitochondria - Danio rerio [Reaction:R-SSC-5205681] Pink1 is cleaved on healthy mitochondria - Sus scrofa [Reaction:R-BTA-5205681] Pink1 is cleaved on healthy mitochondria - Bos taurus [Reaction:R-CFA-5205681] Pink1 is cleaved on healthy mitochondria - Canis familiaris [Reaction:R-RNO-5205681] Pink1 is cleaved on healthy mitochondria - Rattus norvegicus [Reaction:R-MMU-5205681] Pink1 is cleaved on healthy mitochondria - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5205628] PINK1(111-581) [mitochondrial intermembrane space]
precedingEvent	[Reaction:R-HSA-5205661] Pink1 is recruited from the cytoplasm to the mitochondria - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793554] Chauss, Daniel, Kantorow, Marc, 2015-09-01
revised	[InstanceEdit:9638297] Varusai, Thawfeek, 2019-03-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5205681
summation	[Summation:5205632] Full-length PINK1 (63 kDa), which is in the inner mitochondr...
updateTrackers	[UpdateTracker:9863963] Update Tracker - [Reaction:5205681] Pink1 is cleaved on healthy mitochondria - v88:[modifyText] [UpdateTracker:9842312] Update Tracker - [Reaction:5205681] Pink1 is cleaved on healthy mitochondria - v86:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9863963] Update Tracker - [Reaction:5205681] Pink1 is cleaved on healthy mitochondria - v88:[modifyText] [UpdateTracker:9842312] Update Tracker - [Reaction:5205681] Pink1 is cleaved on healthy mitochondria - v86:[modifyText]
(hasEvent)	[Pathway:R-HSA-5205685] PINK1-PRKN Mediated Mitophagy