Reactome | Phosphorylation of beta and gamma subunits by LYN

Schema > Reaction > Entries

Phosphorylation of beta and gamma subunits by LYN Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
catalystActivity	[CatalystActivity:2454172] protein tyrosine kinase activity of p-Y397-LYN [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643249] protein tyrosine kinase activity of p-Y396-LYN [plasma membrane] A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
dbId	2454208
displayName	Phosphorylation of beta and gamma subunits by LYN
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-2454240] Recruitment of SYK to p-FCERI gamma subunit - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2454196] FCERI:IgE:Allergen aggregate [plasma membrane] [EntityWithAccessionedSequence:R-HSA-2454229] p-Y397-LYN [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2454175] Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation [LiteratureReference:2454205] A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation [LiteratureReference:2454177] The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE [LiteratureReference:2454221] Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation [LiteratureReference:2454187] Lipid rafts in mast cell signaling
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Phosphorylation of beta and gamma subunits by LYN
orthologousEvent	[Reaction:R-SSC-2454208] Phosphorylation of beta and gamma subunits by LYN - Sus scrofa [Reaction:R-BTA-2454208] Phosphorylation of beta and gamma subunits by LYN - Bos taurus [Reaction:R-CFA-2454208] Phosphorylation of beta and gamma subunits by LYN - Canis familiaris [Reaction:R-RNO-2454208] Phosphorylation of beta and gamma subunits by LYN - Rattus norvegicus [Reaction:R-MMU-2454208] Phosphorylation of beta and gamma subunits by LYN - Mus musculus
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2454232] Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane]
precedingEvent	[Reaction:R-HSA-2730862] Autophosphorylation of LYN kinase - Homo sapiens [BlackBoxEvent:R-HSA-2454192] Allergen dependent IgE bound FCERI aggregation - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2454208
summation	[Summation:2454176] Upon FCGRI-IgE aggregation, LYN kinase phosphorylates the ty...

Referrals

(hasEvent)	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling
(precedingEvent)	[Reaction:R-HSA-2454240] Recruitment of SYK to p-FCERI gamma subunit