Reactome | Recruitment of SYK to p-FCERI gamma subunit

Schema > Reaction > Entries

Recruitment of SYK to p-FCERI gamma subunit Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
dbId	2454240
displayName	Recruitment of SYK to p-FCERI gamma subunit
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-2454239] Phosphorylation of SYK - Homo sapiens
input	[Complex:R-HSA-2454232] Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] [EntityWithAccessionedSequence:R-HSA-58268] SYK [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2454174] Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor [LiteratureReference:2454247] Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor [LiteratureReference:2454171] Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Recruitment of SYK to p-FCERI gamma subunit
orthologousEvent	[Reaction:R-GGA-2454240] Recruitment of SYK to p-FCERI gamma subunit - Gallus gallus [Reaction:R-SSC-2454240] Recruitment of SYK to p-FCERI gamma subunit - Sus scrofa [Reaction:R-BTA-2454240] Recruitment of SYK to p-FCERI gamma subunit - Bos taurus [Reaction:R-CFA-2454240] Recruitment of SYK to p-FCERI gamma subunit - Canis familiaris [Reaction:R-RNO-2454240] Recruitment of SYK to p-FCERI gamma subunit - Rattus norvegicus [Reaction:R-MMU-2454240] Recruitment of SYK to p-FCERI gamma subunit - Mus musculus
output	[Complex:R-HSA-2454243] Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane]
precedingEvent	[Reaction:R-HSA-2454208] Phosphorylation of beta and gamma subunits by LYN - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2454240
summation	[Summation:2454184] Tyrosine phosphorylated ITAM in FCERI gamma subunit serves a...

Referrals

(hasEvent)	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling
(precedingEvent)	[Reaction:R-HSA-2454239] Phosphorylation of SYK