Reactome | FCERI mediated NF-kB activation

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FCERI mediated NF-kB activation Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:2871805] Garapati, P V, 2012-12-21
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	2871837
displayName	FCERI mediated NF-kB activation
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2730871] RasGRP interacts with DAG and Ca2+ - Homo sapiens [Reaction:R-HSA-202328] Translocation of PKC theta to plasma membrane - Homo sapiens [Reaction:R-HSA-2730882] Phosphorylation of PKC-theta - Homo sapiens [Reaction:R-HSA-2730835] Autophosphorylation of PKC-theta - Homo sapiens [Reaction:R-HSA-2730863] Phosphorylation of CARMA1 by PKC-theta - Homo sapiens [BlackBoxEvent:R-HSA-2730902] Oligomerization of p-CARMA1 - Homo sapiens [Reaction:R-HSA-2730836] Interaction of BCL10:MALT1 with CARMA1 to form CBM complex - Homo sapiens [BlackBoxEvent:R-HSA-2730899] Oligomerization of BCL10 and MALT1 - Homo sapiens [Reaction:R-HSA-2730864] Recruitment of TRAF6 to CBM complex by binding to MALT1 - Homo sapiens [BlackBoxEvent:R-HSA-2730903] Oligomerization of TRAF6 - Homo sapiens [BlackBoxEvent:R-HSA-2730904] Auto-ubiquitination of TRAF6 - Homo sapiens [Reaction:R-HSA-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Homo sapiens [BlackBoxEvent:R-HSA-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Homo sapiens [Reaction:R-HSA-2730876] Phosphorylation of IKK-beta by TAK1 - Homo sapiens [BlackBoxEvent:R-HSA-202534] Ubiquitination of NEMO by TRAF6 - Homo sapiens [Reaction:R-HSA-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Homo sapiens [BlackBoxEvent:R-HSA-5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex - Homo sapiens [BlackBoxEvent:R-HSA-5607724] 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex - Homo sapiens [BlackBoxEvent:R-HSA-2730894] NFKB1:RELA translocates from the cytosol to the nucleus - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:2871812] Proximal signaling events in Fc epsilon RI-mediated mast cell activation [LiteratureReference:2685296] The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	FCERI mediated NF-kB activation
orthologousEvent	[Pathway:R-MMU-2871837] FCERI mediated NF-kB activation - Mus musculus [Pathway:R-RNO-2871837] FCERI mediated NF-kB activation - Rattus norvegicus [Pathway:R-CFA-2871837] FCERI mediated NF-kB activation - Canis familiaris [Pathway:R-BTA-2871837] FCERI mediated NF-kB activation - Bos taurus [Pathway:R-SSC-2871837] FCERI mediated NF-kB activation - Sus scrofa [Pathway:R-XTR-2871837] FCERI mediated NF-kB activation - Xenopus tropicalis [Pathway:R-GGA-2871837] FCERI mediated NF-kB activation - Gallus gallus [Pathway:R-DME-2871837] FCERI mediated NF-kB activation - Drosophila melanogaster [Pathway:R-CEL-2871837] FCERI mediated NF-kB activation - Caenorhabditis elegans [Pathway:R-DDI-2871837] FCERI mediated NF-kB activation - Dictyostelium discoideum [Pathway:R-SPO-2871837] FCERI mediated NF-kB activation - Schizosaccharomyces pombe [Pathway:R-SCE-2871837] FCERI mediated NF-kB activation - Saccharomyces cerevisiae
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2871837
summation	[Summation:2871842] The increase in intracellular Ca+2 in conjunction with DAG a...
updateTrackers	[UpdateTracker:9775124] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v80:[updateContainedRLE] [UpdateTracker:9784762] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v53:[addHasEvent] [UpdateTracker:9780414] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v63:[updateContainedRLE] [UpdateTracker:9776315] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v76:[updateContainedRLE] [UpdateTracker:9782515] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v59:[updateContainedRLE] [UpdateTracker:9781844] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v60:[updateContainedRLE] [UpdateTracker:9786966] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v46:[addLiteratureReference, modifyText] [UpdateTracker:9783138] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v57:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9786158] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v50:[updateContainedRLE] [UpdateTracker:9784931] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v52:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling

(updatedInstance)

[UpdateTracker:9775124] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v80:[updateContainedRLE]
[UpdateTracker:9784762] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v53:[addHasEvent]
[UpdateTracker:9780414] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v63:[updateContainedRLE]
[UpdateTracker:9776315] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v76:[updateContainedRLE]
[UpdateTracker:9782515] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v59:[updateContainedRLE]
[UpdateTracker:9781844] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v60:[updateContainedRLE]
[UpdateTracker:9786966] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v46:[addLiteratureReference, modifyText]
[UpdateTracker:9783138] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v57:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9786158] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v50:[updateContainedRLE]
[UpdateTracker:9784931] Update Tracker - [Pathway:2871837] FCERI mediated NF-kB activation - v52:[updateContainedRLE]

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