Reactome | FCERI mediated Ca+2 mobilization

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FCERI mediated Ca+2 mobilization Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:2871805] Garapati, P V, 2012-12-21
crossReference	[DatabaseIdentifier:12819579] BioModels Database:BIOMD0000000464 [DatabaseIdentifier:12819463] BioModels Database:BIOMD0000000088 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468
dbId	2871809
displayName	FCERI mediated Ca+2 mobilization
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2730885] Recruitment of TEC kinases to p-SLP-76 - Homo sapiens [Reaction:R-HSA-2730833] Phosphorylation of TEC kinases by p-SYK - Homo sapiens [Reaction:R-HSA-2730858] Autophosphorylation of BTK/ITK - Homo sapiens [Reaction:R-HSA-2730888] Phosphorylation of PLC-gamma - Homo sapiens [Reaction:R-HSA-2730847] Hydrolysis of PIP2 by PLCG - Homo sapiens [Reaction:R-HSA-169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - Homo sapiens [Reaction:R-HSA-169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol - Homo sapiens [Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens [Reaction:R-HSA-2730872] Activation of Calcineurin - Homo sapiens [BlackBoxEvent:R-HSA-2730849] Calcineurin binds and dephosphorylates NFAT - Homo sapiens [Reaction:R-HSA-2730867] Translocation of CaN:CaM:NFAT to nucleus - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-12-13
literatureReference	[LiteratureReference:2871791] Depletion of intracellular calcium stores activates a calcium current in mast cells [LiteratureReference:2871812] Proximal signaling events in Fc epsilon RI-mediated mast cell activation [LiteratureReference:2871790] RasGRP links T-cell receptor signaling to Ras
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	FCERI mediated Ca+2 mobilization
orthologousEvent	[Pathway:R-CEL-2871809] FCERI mediated Ca+2 mobilization - Caenorhabditis elegans [Pathway:R-DME-2871809] FCERI mediated Ca+2 mobilization - Drosophila melanogaster [Pathway:R-GGA-2871809] FCERI mediated Ca+2 mobilization - Gallus gallus [Pathway:R-XTR-2871809] FCERI mediated Ca+2 mobilization - Xenopus tropicalis [Pathway:R-DRE-2871809] FCERI mediated Ca+2 mobilization - Danio rerio [Pathway:R-SSC-2871809] FCERI mediated Ca+2 mobilization - Sus scrofa [Pathway:R-BTA-2871809] FCERI mediated Ca+2 mobilization - Bos taurus [Pathway:R-CFA-2871809] FCERI mediated Ca+2 mobilization - Canis familiaris [Pathway:R-RNO-2871809] FCERI mediated Ca+2 mobilization - Rattus norvegicus [Pathway:R-MMU-2871809] FCERI mediated Ca+2 mobilization - Mus musculus
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2871809
summation	[Summation:2871813] Increase of intracellular calcium in mast cells is most cruc...
updateTrackers	[UpdateTracker:9780804] Update Tracker - [Pathway:2871809] FCERI mediated Ca+2 mobilization - v62:[updateContainedRLE] [UpdateTracker:9785194] Update Tracker - [Pathway:2871809] FCERI mediated Ca+2 mobilization - v52:[updateContainedRLE] [UpdateTracker:9778805] Update Tracker - [Pathway:2871809] FCERI mediated Ca+2 mobilization - v67:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9780804] Update Tracker - [Pathway:2871809] FCERI mediated Ca+2 mobilization - v62:[updateContainedRLE] [UpdateTracker:9785194] Update Tracker - [Pathway:2871809] FCERI mediated Ca+2 mobilization - v52:[updateContainedRLE] [UpdateTracker:9778805] Update Tracker - [Pathway:2871809] FCERI mediated Ca+2 mobilization - v67:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling

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