Reactome | Allergen dependent IgE bound FCERI aggregation

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Allergen dependent IgE bound FCERI aggregation Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
dbId	2454192
displayName	Allergen dependent IgE bound FCERI aggregation
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-2454208] Phosphorylation of beta and gamma subunits by LYN - Homo sapiens
input	[OtherEntity:R-ALL-2454186] Allergen [extracellular region] 5 × [Complex:R-HSA-2454224] FCERI:IgE [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2454245] Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha [LiteratureReference:2454201] Mast cell signal transduction from the high-affinity IgE receptor [LiteratureReference:2685294] Insights into immunoglobulin E receptor signaling from structurally defined ligands
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Allergen dependent IgE bound FCERI aggregation
orthologousEvent	[BlackBoxEvent:R-SSC-2454192] Allergen dependent IgE bound FCERI aggregation - Sus scrofa [BlackBoxEvent:R-BTA-2454192] Allergen dependent IgE bound FCERI aggregation - Bos taurus [BlackBoxEvent:R-CFA-2454192] Allergen dependent IgE bound FCERI aggregation - Canis familiaris [BlackBoxEvent:R-RNO-2454192] Allergen dependent IgE bound FCERI aggregation - Rattus norvegicus [BlackBoxEvent:R-MMU-2454192] Allergen dependent IgE bound FCERI aggregation - Mus musculus
output	[Complex:R-HSA-2454196] FCERI:IgE:Allergen aggregate [plasma membrane]
precedingEvent	[Reaction:R-HSA-9725206] IgE binds FCERI - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2454192
summation	[Summation:2454178] FCERI is primarily expressed on mast cells and basophils as ...

Referrals

(hasEvent)	[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling
(precedingEvent)	[Reaction:R-HSA-2454208] Phosphorylation of beta and gamma subunits by LYN

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