Reactome | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
created	[InstanceEdit:2173792] Orlic-Milacic, M, 2012-04-02
crossReference	[DatabaseIdentifier:12819607] BioModels Database:BIOMD0000000997 [DatabaseIdentifier:12819609] BioModels Database:BIOMD0000000342 [DatabaseIdentifier:12819611] BioModels Database:BIOMD0000001001 [DatabaseIdentifier:12819613] BioModels Database:BIOMD0000001003 [DatabaseIdentifier:12819615] BioModels Database:BIOMD0000000989 [DatabaseIdentifier:12819617] BioModels Database:BIOMD0000000499 [DatabaseIdentifier:12819619] BioModels Database:BIOMD0000000995 [DatabaseIdentifier:12819621] BioModels Database:BIOMD0000000173 [DatabaseIdentifier:12819623] BioModels Database:BIOMD0000000998 [DatabaseIdentifier:12819625] BioModels Database:BIOMD0000000996 [DatabaseIdentifier:12819627] BioModels Database:BIOMD0000000990 [DatabaseIdentifier:12819629] BioModels Database:BIOMD0000001000 [DatabaseIdentifier:12819631] BioModels Database:BIOMD0000000999 [DatabaseIdentifier:12819635] BioModels Database:BIOMD0000001002 [DatabaseIdentifier:12819637] BioModels Database:BIOMD0000000994
dbId	2173796
displayName	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Homo sapiens [BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens [Reaction:R-HSA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Homo sapiens [Reaction:R-HSA-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens [BlackBoxEvent:R-HSA-2106579] WWTR1:SMAD translocates to the nucleus - Homo sapiens [Reaction:R-HSA-9736959] WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - Homo sapiens [Reaction:R-HSA-2186771] RNF111 binds SMAD7 - Homo sapiens [Reaction:R-HSA-2186785] RNF111 ubiquitinates SMAD7 - Homo sapiens [BlackBoxEvent:R-HSA-2186780] Degradation of Ub-SMAD7 - Homo sapiens [Reaction:R-HSA-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 - Homo sapiens [Reaction:R-HSA-9736984] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-1484099] MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex - Homo sapiens [Reaction:R-HSA-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 - Homo sapiens [Reaction:R-HSA-9736979] p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-2187303] SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B - Homo sapiens [Reaction:R-HSA-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Homo sapiens [Reaction:R-HSA-9736992] p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-2187293] SMAD2/3:SMAD4 complex positively regulates JUNB transcription - Homo sapiens [BlackBoxEvent:R-HSA-9733203] FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 - Homo sapiens [BlackBoxEvent:R-HSA-9736953] FURIN translocates to the plasma membrane - Homo sapiens [Reaction:R-HSA-9733207] p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9733216] COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 - Homo sapiens [Reaction:R-HSA-9733247] YBX1 binds COL1A2 gene promoter - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:178143] An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity [LiteratureReference:173516] The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation [LiteratureReference:178148] Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner [LiteratureReference:2176478] Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways [LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal [LiteratureReference:2186773] Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 [LiteratureReference:1484105] E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression [LiteratureReference:1181277] Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta [LiteratureReference:2186647] Impaired Transforming Growth Factor-? (TGF-?) Transcriptional Activity and Cell Proliferation Control of a Menin In-frame Deletion Mutant Associated with Multiple Endocrine Neoplasia Type 1 (MEN1) [LiteratureReference:2186644] Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling [LiteratureReference:2186646] Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2 [LiteratureReference:2187286] Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
orthologousEvent	[Pathway:R-PFA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Plasmodium falciparum [Pathway:R-SCE-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Saccharomyces cerevisiae [Pathway:R-SPO-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Schizosaccharomyces pombe [Pathway:R-MMU-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Mus musculus [Pathway:R-RNO-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Rattus norvegicus [Pathway:R-CFA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Canis familiaris [Pathway:R-BTA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Bos taurus [Pathway:R-SSC-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Sus scrofa [Pathway:R-DRE-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Danio rerio [Pathway:R-XTR-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Xenopus tropicalis [Pathway:R-GGA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Gallus gallus [Pathway:R-DME-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Drosophila melanogaster [Pathway:R-CEL-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Caenorhabditis elegans
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2173796
summation	[Summation:2190615] After phosphorylated SMAD2 and/or SMAD3 form a heterotrimer ...
updateTrackers	[UpdateTracker:9775792] Update Tracker - [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - v78:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9775070] Update Tracker - [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - v80:[updateContainedRLE] [UpdateTracker:9785041] Update Tracker - [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - v52:[addHasEvent, updateContainedRLE] [UpdateTracker:9787934] Update Tracker - [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - v44:[updateContainedRLE] [UpdateTracker:9774758] Update Tracker - [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - v81:[addHasEvent, updateContainedRLE] [UpdateTracker:9788253] Update Tracker - [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - v43:[updateContainedRLE]

Referrals

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[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

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