Reactome | WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter

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WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9736957] Orlic-Milacic, Marija, 2021-07-15
dbId	9736959
displayName	WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter
edited	[InstanceEdit:9736986] Orlic-Milacic, Marija, 2021-07-15 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2106592] SERPINE1 gene [nucleoplasm] [Complex:R-HSA-2106580] WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter
output	[Complex:R-HSA-9736958] WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-2106579] WWTR1:SMAD translocates to the nucleus - Homo sapiens [Reaction:R-HSA-9736966] SMAD7 binds SERPINE1 gene promoter - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-3009212] Negative regulation by 'SMAD7:SERPINE1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642406] Negative regulation by 'SMAD7:SERPINE1 gene [nucleoplasm]' Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
revised	[InstanceEdit:9736955] Orlic-Milacic, Marija, 2021-07-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9736959
summation	[Summation:9736956] By chromatin immunoprecipitation (ChIP) it was shown that bo...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
(hasEvent)	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

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