Reactome | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649642
displayName	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
eventOf	[Pathway:R-DRE-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-DRE-2106579] WWTR1:SMAD translocates to the nucleus - Danio rerio [BlackBoxEvent:R-DRE-2186780] Degradation of Ub-SMAD7 - Danio rerio [BlackBoxEvent:R-DRE-9736953] FURIN translocates to the plasma membrane - Danio rerio
inferredFrom	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-2173796
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
(inferredTo)	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

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