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Schema
>
BlackBoxEvent
>
Entries
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
Show undefined attributes
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authored
[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category
omitted
compartment
[Compartment:984] extracellular region
[Compartment:7660] nucleoplasm
created
[InstanceEdit:2106589] Orlic-Milacic, M, 2012-02-10
dbId
2106586
displayName
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
edited
[InstanceEdit:2187413] Jassal, B, 2012-04-10
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-2106592] SERPINE1 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
[LiteratureReference:480195] TGIF2 interacts with histone deacetylase 1 and represses transcription
[LiteratureReference:2186605] A Smad transcriptional corepressor
[LiteratureReference:3009225] Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
output
[EntityWithAccessionedSequence:R-HSA-158797] SERPINE1 [extracellular region]
precedingEvent
[Reaction:R-HSA-9736959] WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter - Homo sapiens
[Reaction:R-HSA-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:R-HSA-2106588] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:R-HSA-2186613] Negative gene expression regulation by 'p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]'
regulationReference
[RegulationReference:9642406] Negative regulation by 'SMAD7:SERPINE1 gene [nucleoplasm]' Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
[RegulationReference:9642541] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene [nucleoplasm]' TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
[RegulationReference:9642819] Negative gene expression regulation by 'p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]' TGIF2 interacts with histone deacetylase 1 and represses transcription
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2250308] Huang, Tao, 2012-05-14
[InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
[InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
revised
[InstanceEdit:3009218] Orlic-Milacic, M, 2013-02-04
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-2106586
summation
[Summation:2106594] Knocking down WWTR1 (TAZ) expression by siRNA treatment inhi...
updateTrackers
[UpdateTracker:9775055] Update Tracker - [BlackBoxEvent:2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - v80:[add_removeOutput]
[UpdateTracker:9775695] Update Tracker - [BlackBoxEvent:2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - v78:[add_removeRegulator, modifyText]
[UpdateTracker:9788103] Update Tracker - [BlackBoxEvent:2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - v44:[addLiteratureReference, addRegulator, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775055] Update Tracker - [BlackBoxEvent:2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - v80:[add_removeOutput]
[UpdateTracker:9775695] Update Tracker - [BlackBoxEvent:2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - v78:[add_removeRegulator, modifyText]
[UpdateTracker:9788103] Update Tracker - [BlackBoxEvent:2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it - v44:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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