Reactome | RNF111 ubiquitinates SMAD7

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RNF111 ubiquitinates SMAD7 Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
catalystActivity	[CatalystActivity:2186782] ubiquitin-protein transferase activity of SMAD7:RNF111 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2186783] Orlic-Milacic, M, 2012-04-05
dbId	2186785
displayName	RNF111 ubiquitinates SMAD7
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2186780] Degradation of Ub-SMAD7 - Homo sapiens
inferredFrom	[Reaction:R-NUL-2186775] Rnf111 ubiquitinates Smad7 - Homo sapiens
input	[Complex:R-HSA-2186769] SMAD7:RNF111 [nucleoplasm] [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2186773] Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNF111 ubiquitinates SMAD7
output	[EntityWithAccessionedSequence:R-HSA-2186765] RNF111 [nucleoplasm] [Complex:R-HSA-2186778] Ub-SMAD7 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2186771] RNF111 binds SMAD7 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2186785
summation	[Summation:2186776] RNF111 (Arkadia) polyubiquitinates SMAD7 (Koinuma et al. 200...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-2186780] Degradation of Ub-SMAD7 [NegativePrecedingEvent:9754411] Futile Cycle: RNF111 ubiquitinates SMAD7 [NegativePrecedingEvent:9754416] Futile Cycle: RNF111 ubiquitinates SMAD7
(hasEvent)	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(inferredTo)	[Reaction:R-NUL-2186775] Rnf111 ubiquitinates Smad7

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