Reactome | WWTR1 binds SMAD2/3:SMAD4 heterotrimer

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WWTR1 binds SMAD2/3:SMAD4 heterotrimer Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2031356] Orlic-Milacic, M, 2012-01-05
dbId	2031355
displayName	WWTR1 binds SMAD2/3:SMAD4 heterotrimer
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2106579] WWTR1:SMAD translocates to the nucleus - Homo sapiens
input	[DefinedSet:R-HSA-171175] p-2S-SMAD2,3:SMAD4 [cytosol] [EntityWithAccessionedSequence:R-HSA-1629773] WWTR1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WWTR1 binds SMAD2/3:SMAD4 heterotrimer
orthologousEvent	[Reaction:R-CEL-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Caenorhabditis elegans [Reaction:R-DME-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Drosophila melanogaster [Reaction:R-GGA-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Gallus gallus [Reaction:R-XTR-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Xenopus tropicalis [Reaction:R-SSC-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Sus scrofa [Reaction:R-BTA-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Bos taurus [Reaction:R-CFA-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Canis familiaris [Reaction:R-RNO-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Rattus norvegicus [Reaction:R-MMU-2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer - Mus musculus
output	[Complex:R-HSA-2031357] WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol]
precedingEvent	[Reaction:R-HSA-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2031355
summation	[Summation:2031343] In the cytosol of human embryonic stem cells, WWTR1 (TAZ) bi...

Referrals

(hasEvent)	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-2106579] WWTR1:SMAD translocates to the nucleus