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Schema
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Reaction
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Entries
p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter
Show undefined attributes
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authored
[InstanceEdit:9733215] Orlic-Milacic, Marija, 2021-06-01
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9733209] Orlic-Milacic, Marija, 2021-06-01
dbId
9733207
displayName
p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter
edited
[InstanceEdit:9773649] Orlic-Milacic, Marija, 2022-05-09
eventOf
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9733216] COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-6789344] COL1A2 gene [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm]
[Complex:R-HSA-8878153] p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1592223] SP1 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9733230] Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
[LiteratureReference:9733236] Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis
[LiteratureReference:9733245] Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts
[LiteratureReference:9737487] Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter
negativePrecedingEvent
[NegativePrecedingEvent:9754422] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
output
[Complex:R-HSA-9733206] p-2S-SMAD3:p-2S-SMAD3:SMAD4:SP1:EP300:COL1A2 gene [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate
2022-06-09
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9733207
summation
[Summation:9737485] The heterotrimer composed of SMAD4 and two molecules of phos...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-9733216] COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4
(hasEvent)
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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