Reactome | MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex

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MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1484101] Orlic-Milacic, Marija, 2011-08-12
dbId	1484099
displayName	MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
followingEvent	[Reaction:R-HSA-8932400] MYC:MAX binds the CDC25A gene - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2127254] MYC gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1484105] E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
output	[EntityWithAccessionedSequence:R-HSA-188379] MYC [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9736984] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-1484103] Negative gene expression regulation by 'p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2:MYC gene [nucleoplasm]'
regulationReference	[RegulationReference:9642025] Negative gene expression regulation by 'p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2:MYC gene [nucleoplasm]' E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1484099
summation	[Summation:1484104] Complex formed by RBL1 (p107), E2F4/5, DP1/2 and a trimer of...
updateTrackers	[UpdateTracker:9775531] Update Tracker - [BlackBoxEvent:1484099] MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex - v78:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9775531] Update Tracker - [BlackBoxEvent:1484099] MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex - v78:[add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(precedingEvent)	[Reaction:R-HSA-8932400] MYC:MAX binds the CDC25A gene

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