Reactome | PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

Schema > Reaction > Entries

PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806282] phosphatidylinositol kinase activity of PIP5K1A-C [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId	1675773
displayName	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675808] Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules [LiteratureReference:1675873] Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate [LiteratureReference:1676009] PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse [LiteratureReference:480180] Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin [LiteratureReference:1676172] ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
orthologousEvent	[Reaction:R-MMU-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Mus musculus [Reaction:R-PFA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Plasmodium falciparum [Reaction:R-SPO-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-RNO-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Rattus norvegicus [Reaction:R-CFA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Canis familiaris [Reaction:R-SCE-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-DDI-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Dictyostelium discoideum [Reaction:R-CEL-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Gallus gallus [Reaction:R-XTR-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Danio rerio [Reaction:R-SSC-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Sus scrofa [Reaction:R-BTA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Bos taurus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1675773
summation	[Summation:1675879] At the plasma membrane, phosphatidylinositol-4-phosphate 5-k...

Referrals

(hasEvent)	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane
(precedingEvent)	[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 [Reaction:R-HSA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

Cite Us!