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Entries
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane
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authored
[InstanceEdit:8849956] Jupe, Steve, 2015-12-18
catalystActivity
[CatalystActivity:8849954] phosphatidylinositol phosphate 4-phosphatase activity of INPP5F [early endosome membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:171062] early endosome membrane
created
[InstanceEdit:8849956] Jupe, Steve, 2015-12-18
dbId
8849969
displayName
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane
edited
[InstanceEdit:8850893] Jupe, Steve, 2016-01-04
eventOf
[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[DefinedSet:R-ALL-8849959] PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3 [early endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8850885] Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane
orthologousEvent
[Reaction:R-PFA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Plasmodium falciparum
[Reaction:R-DDI-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Dictyostelium discoideum
[Reaction:R-CEL-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Caenorhabditis elegans
[Reaction:R-DME-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Drosophila melanogaster
[Reaction:R-GGA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Gallus gallus
[Reaction:R-XTR-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Xenopus tropicalis
[Reaction:R-DRE-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Danio rerio
[Reaction:R-SSC-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Sus scrofa
[Reaction:R-BTA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Bos taurus
[Reaction:R-CFA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Canis familiaris
[Reaction:R-RNO-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Rattus norvegicus
[Reaction:R-MMU-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Mus musculus
output
[SimpleEntity:R-ALL-29372] Pi [cytosol]
[DefinedSet:R-ALL-8849958] PI5P, PI3P, PI(3,5)P2 [early endosome membrane]
precedingEvent
[Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Homo sapiens
[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens
[Reaction:R-HSA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Homo sapiens
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8851286] D'Eustachio, Peter, 2016-01-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8849969
summation
[Summation:8849965] Characterization of human INPP5F (SAC2) identified that it i...
Referrals
(hasEvent)
[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane
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