Reactome | PTEN mRNA translation is negatively regulated by microRNAs

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PTEN mRNA translation is negatively regulated by microRNAs Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8944495] Orlic-Milacic, Marija, 2016-11-03
dbId	8944497
displayName	PTEN mRNA translation is negatively regulated by microRNAs
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-8943723] Regulation of PTEN mRNA translation - Homo sapiens
followingEvent	[Reaction:R-HSA-8948800] TNKS and TNKS2 PARylate PTEN - Homo sapiens [Reaction:R-HSA-8847968] PTEN binds FRK - Homo sapiens [Reaction:R-HSA-8850945] Casein kinase II phosphorylates PTEN - Homo sapiens [Reaction:R-HSA-8850997] TRIM27 binds PTEN - Homo sapiens [Reaction:R-HSA-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Homo sapiens [Pathway:R-HSA-8948747] Regulation of PTEN localization - Homo sapiens [Reaction:R-HSA-8948775] MKRN1 polyubiquitinates PTEN - Homo sapiens [Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2318746] PTEN mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2318761] The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo [LiteratureReference:8943431] miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer [LiteratureReference:2325197] Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship [LiteratureReference:8944704] MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC) [LiteratureReference:8943408] MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer [LiteratureReference:8943351] Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation [LiteratureReference:8943446] Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs [LiteratureReference:8944681] MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN [LiteratureReference:8943362] Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes [LiteratureReference:8943367] MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTEN mRNA translation is negatively regulated by microRNAs
output	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol]
precedingEvent	[Reaction:R-HSA-2318752] miR-26A microRNAs bind PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944483] miR-17 microRNA binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944522] miR-19a microRNA binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8948569] miR-19b microRNA binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8945709] miR-20 microRNAs bind PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944706] miR-21 nonendonucleolytic RISC binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944538] miR-22 microRNA binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944569] miR-25 microRNA binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944599] miR-93 microRNA binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944632] miR-106 microRNAs bind PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944684] miR-205 microRNA binds PTEN mRNA - Homo sapiens [Reaction:R-HSA-8944650] miR-214 microRNA binds PTEN mRNA - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-8944496] Negative gene expression regulation by 'miR-17 RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944498] Negative gene expression regulation by 'PTEN mRNA:miR-26A RISC [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944520] Negative gene expression regulation by 'miR-19a RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944555] Negative gene expression regulation by 'miR-22 RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944583] Negative gene expression regulation by 'miR-25 RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944610] Negative gene expression regulation by 'miR-93:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944630] Negative gene expression regulation by 'miR-106 RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944648] Negative gene expression regulation by 'miR-214 Nonendonucleolytic RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8944677] Negative gene expression regulation by 'miR-205 RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8945691] Negative gene expression regulation by 'miR-20 RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8945715] Negative gene expression regulation by 'miR-21 Nonendonucleolytic RISC:PTEN mRNA [cytosol]' [NegativeGeneExpressionRegulation:R-HSA-8948566] Negative gene expression regulation by 'miR-19b RISC:PTEN mRNA [cytosol]'
regulationReference	[RegulationReference:9641291] Negative gene expression regulation by 'miR-22 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation [RegulationReference:9641604] Negative gene expression regulation by 'miR-17 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation [RegulationReference:9641697] Negative gene expression regulation by 'miR-19b RISC:PTEN mRNA [cytosol]' Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes [RegulationReference:9641726] Negative gene expression regulation by 'miR-20 RISC:PTEN mRNA [cytosol]' A coding-independent function of gene and pseudogene mRNAs regulates tumour biology [RegulationReference:9641817] Negative gene expression regulation by 'miR-106 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation [RegulationReference:9641860] Negative gene expression regulation by 'miR-205 RISC:PTEN mRNA [cytosol]' MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN [RegulationReference:9641958] Negative gene expression regulation by 'miR-19a RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation [RegulationReference:9642001] Negative gene expression regulation by 'PTEN mRNA:miR-26A RISC [cytosol]' The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo [RegulationReference:9642583] Negative gene expression regulation by 'miR-25 RISC:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation [RegulationReference:9642645] Negative gene expression regulation by 'miR-93:PTEN mRNA [cytosol]' Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation [RegulationReference:9642756] Negative gene expression regulation by 'miR-214 Nonendonucleolytic RISC:PTEN mRNA [cytosol]' MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN [RegulationReference:9642979] Negative gene expression regulation by 'miR-21 Nonendonucleolytic RISC:PTEN mRNA [cytosol]' MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13 [InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8944497
summation	[Summation:2321901] PTEN protein synthesis is negatively regulated by microRNAs ...

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[Pathway:R-HSA-8943723] Regulation of PTEN mRNA translation

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