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Schema
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Reaction
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Entries
Phosphorylation of complexed TSC2 by PKB
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authored
[InstanceEdit:5667118] Jupe, Steve, 2015-01-23
catalystActivity
[CatalystActivity:9975699] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:165161] de Bono, B, 2005-08-01 10:10:30
dbId
165182
displayName
Phosphorylation of complexed TSC2 by PKB
eventOf
[Pathway:R-HSA-165181] Inhibition of TSC complex formation by AKT (PKB) - Homo sapiens
input
3 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-165175] TSC1:TSC2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:532189] Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
maxDepth
1
modified
[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name
Phosphorylation of complexed TSC2 by PKB
orthologousEvent
[Reaction:R-SPO-165182] Phosphorylation of complexed TSC2 by PKB - Schizosaccharomyces pombe
[Reaction:R-DME-165182] Phosphorylation of complexed TSC2 by PKB - Drosophila melanogaster
[Reaction:R-GGA-165182] Phosphorylation of complexed TSC2 by PKB - Gallus gallus
[Reaction:R-SSC-165182] Phosphorylation of complexed TSC2 by PKB - Sus scrofa
[Reaction:R-BTA-165182] Phosphorylation of complexed TSC2 by PKB - Bos taurus
[Reaction:R-CFA-165182] Phosphorylation of complexed TSC2 by PKB - Canis familiaris
[Reaction:R-RNO-165182] Phosphorylation of complexed TSC2 by PKB - Rattus norvegicus
[Reaction:R-MMU-165182] Phosphorylation of complexed TSC2 by PKB - Mus musculus
output
3 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-165180] TSC1:Inhibited TSC2-1-P [cytosol]
precedingEvent
[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2006-04-24
reviewStatus
[ReviewStatus:9821385] four stars
reviewed
[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised
[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-165182
summation
[Summation:179051] Phosphorylation of TSC2 by AKT (PKB) disrupts TSC1:TSC2 hete...
updateTrackers
[UpdateTracker:9911021] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v89:[modifyText]
[UpdateTracker:9984595] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v96:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9784835] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v53:[add_removeLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9911021] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v89:[modifyText]
[UpdateTracker:9984595] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v96:[add_removeCatalystActivity, modifyText]
[UpdateTracker:9784835] Update Tracker - [Reaction:165182] Phosphorylation of complexed TSC2 by PKB - v53:[add_removeLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-165181] Inhibition of TSC complex formation by AKT (PKB)
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