Reactome | AKT phosphorylates AKT1S1 (PRAS40)

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AKT phosphorylates AKT1S1 (PRAS40) Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200149] Jassal, B, 2007-07-16 08:38:43
dbId	200143
diseaseReaction	[Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) - Homo sapiens
displayName	AKT phosphorylates AKT1S1 (PRAS40)
eventOf	[Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
input	[EntityWithAccessionedSequence:R-HSA-200155] AKT1S1 [cytosol] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200154] Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	AKT phosphorylates AKT1S1 (PRAS40)
orthologousEvent	[Reaction:R-DME-200143] AKT phosphorylates AKT1S1 (PRAS40) - Drosophila melanogaster [Reaction:R-DRE-200143] AKT phosphorylates AKT1S1 (PRAS40) - Danio rerio [Reaction:R-RNO-200143] AKT phosphorylates AKT1S1 (PRAS40) - Rattus norvegicus [Reaction:R-MMU-200143] AKT phosphorylates AKT1S1 (PRAS40) - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-200163] p-S183,S221,T246-AKT1S1 [cytosol]
precedingEvent	[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200143
summation	[Summation:200160] PRAS40 (proline-rich Akt/PKB substrate 40 kDa) is a substrat...

Referrals

(normalReaction)	[Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
(hasEvent)	[Pathway:R-HSA-198323] AKT phosphorylates targets in the cytosol

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