Reactome | AKT interacts and phosphorylates Cot

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AKT interacts and phosphorylates Cot Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
catalystActivity	[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:389760] Garapati, P V, 2009-01-13 00:49:23
dbId	389756
displayName	AKT interacts and phosphorylates Cot
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-392530] p-S400-Cot phosphorylates NIK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-389388] MAP3K8 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389687] Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	AKT interacts and phosphorylates Cot
orthologousEvent	[Reaction:R-SCE-389756] AKT interacts and phosphorylates Cot - Saccharomyces cerevisiae [Reaction:R-GGA-389756] AKT interacts and phosphorylates Cot - Gallus gallus [Reaction:R-DRE-389756] AKT interacts and phosphorylates Cot - Danio rerio [Reaction:R-RNO-389756] AKT interacts and phosphorylates Cot - Rattus norvegicus [Reaction:R-MMU-389756] AKT interacts and phosphorylates Cot - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-389738] p-S400-MAP3K8 [cytosol]
precedingEvent	[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389756
summation	[Summation:389728] Cot/Tpl 2 is a serine/threonine kinase of the mitogen activa...
updateTrackers	[UpdateTracker:9788326] Update Tracker - [Reaction:389756] AKT interacts and phosphorylates Cot - v42:[add_removeOutput, removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9788326] Update Tracker - [Reaction:389756] AKT interacts and phosphorylates Cot - v42:[add_removeOutput, removeInput]
(hasEvent)	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling
(precedingEvent)	[Reaction:R-HSA-392530] p-S400-Cot phosphorylates NIK

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