Reactome | PIP3 recruits PDK1 and AKT to the membrane

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PIP3 recruits PDK1 and AKT to the membrane Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9603278] Varusai, Thawfeek, 2018-03-16
dbId	9603279
displayName	PIP3 recruits PDK1 and AKT to the membrane
eventOf	[Pathway:R-HSA-392451] G beta:gamma signalling through PI3Kgamma - Homo sapiens
input	[CandidateSet:R-HSA-202088] AKT [cytosol] [EntityWithAccessionedSequence:R-HSA-202210] PDPK1 [cytosol] 2 × [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199317] Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	PIP3 recruits PDK1 and AKT to the membrane
orthologousEvent	[Reaction:R-SCE-9603279] PIP3 recruits PDK1 and AKT to the membrane - Saccharomyces cerevisiae [Reaction:R-SPO-9603279] PIP3 recruits PDK1 and AKT to the membrane - Schizosaccharomyces pombe [Reaction:R-DDI-9603279] PIP3 recruits PDK1 and AKT to the membrane - Dictyostelium discoideum [Reaction:R-CEL-9603279] PIP3 recruits PDK1 and AKT to the membrane - Caenorhabditis elegans [Reaction:R-DME-9603279] PIP3 recruits PDK1 and AKT to the membrane - Drosophila melanogaster [Reaction:R-GGA-9603279] PIP3 recruits PDK1 and AKT to the membrane - Gallus gallus [Reaction:R-DRE-9603279] PIP3 recruits PDK1 and AKT to the membrane - Danio rerio [Reaction:R-RNO-9603279] PIP3 recruits PDK1 and AKT to the membrane - Rattus norvegicus [Reaction:R-MMU-9603279] PIP3 recruits PDK1 and AKT to the membrane - Mus musculus
output	[Complex:R-HSA-198360] PDK1:AKT:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens [Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens [Reaction:R-HSA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens [Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
releaseDate	2007-11-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9603279
summation	[Summation:198339] Phosphatidylinositides generated by PI3K recruit phosphatidy...

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(hasEvent)

[Pathway:R-HSA-392451] G beta:gamma signalling through PI3Kgamma

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