Reactome | PI3K produces PIP3 and other phosphatidyl inositides

PI3K produces PIP3 and other phosphatidyl inositides

Stable Identifier

R-HSA-198266

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytoplasmic side of plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PI3K produces PIP3 and other phosphatidyl inositides

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In line with activation of PI3-kinase (PI3K) by other receptor tyrosine kinases, PI3K recruited to the activated NTRK1 receptor via IRS1 and/or IRS2 (Miranda et al. 2001) is thought to phosphorylate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, commonly known as PtdIn(4,5)P2 or PIP2, at the plasma membrane producing the second messenger PtdIns(3,4,5)P3, also named PIP3, as evidenced by increased PIP3 levels (Miranda et al. 2001) and increased activating phosphorylation of AKT1 (Tsuchiya et al. 2014) upon stimulation of cells with the NTRK1 ligand NGF.

Literature References

PubMed ID	Title	Journal	Year
11147812	IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1 Miranda, C, Greco, A, Miele, C, Pierotti, MA, Van Obberghen, E	J Cell Physiol	2001