Reactome | PI3K/AKT activation

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PI3K/AKT activation Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
created	[InstanceEdit:198207] Jassal, Bijay, 2007-05-21
crossReference	[DatabaseIdentifier:12819467] BioModels Database:BIOMD0000000581
dbId	198203
displayName	PI3K/AKT activation
eventOf	[Pathway:R-HSA-187037] Signaling by NTRK1 (TRKA) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-198211] Active TRKA binds IRS1/2 - Homo sapiens [Reaction:R-HSA-198295] TRKA phosphorylates IRS - Homo sapiens [Reaction:R-HSA-198315] Active IRS recruits PI3K to the plasma membrane and activates it - Homo sapiens [BlackBoxEvent:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens [Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:202064] Raf and akt mediate distinct aspects of sensory axon growth [LiteratureReference:202689] Signaling by distinct classes of phosphoinositide 3-kinases
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	PI3K/AKT activation
orthologousEvent	[Pathway:R-MMU-198203] PI3K/AKT activation - Mus musculus [Pathway:R-SCE-198203] PI3K/AKT activation - Saccharomyces cerevisiae [Pathway:R-SPO-198203] PI3K/AKT activation - Schizosaccharomyces pombe [Pathway:R-CEL-198203] PI3K/AKT activation - Caenorhabditis elegans [Pathway:R-DME-198203] PI3K/AKT activation - Drosophila melanogaster [Pathway:R-GGA-198203] PI3K/AKT activation - Gallus gallus [Pathway:R-XTR-198203] PI3K/AKT activation - Xenopus tropicalis [Pathway:R-DRE-198203] PI3K/AKT activation - Danio rerio [Pathway:R-SSC-198203] PI3K/AKT activation - Sus scrofa [Pathway:R-BTA-198203] PI3K/AKT activation - Bos taurus [Pathway:R-CFA-198203] PI3K/AKT activation - Canis familiaris [Pathway:R-RNO-198203] PI3K/AKT activation - Rattus norvegicus
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-198203
summation	[Summation:198205] PI3K/AKT signalling is a major regulator of neuron survival...
updateTrackers	[UpdateTracker:9789739] Update Tracker - [Pathway:198203] PI3K/AKT activation - v37:[add_removeHasEvent] [UpdateTracker:9911069] Update Tracker - [Pathway:198203] PI3K/AKT activation - v89:[updateContainedRLE] [UpdateTracker:9789311] Update Tracker - [Pathway:198203] PI3K/AKT activation - v38:[addLiteratureReference, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9780778] Update Tracker - [Pathway:198203] PI3K/AKT activation - v62:[removeHasEvent] [UpdateTracker:9782164] Update Tracker - [Pathway:198203] PI3K/AKT activation - v59:[updateIndirectRLE] [UpdateTracker:9783820] Update Tracker - [Pathway:198203] PI3K/AKT activation - v55:[updateIndirectRLE] [UpdateTracker:9781486] Update Tracker - [Pathway:198203] PI3K/AKT activation - v61:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791340] Update Tracker - [Pathway:198203] PI3K/AKT activation - v31:[updateContainedRLE] [UpdateTracker:9782931] Update Tracker - [Pathway:198203] PI3K/AKT activation - v58:[updateContainedPathway] [UpdateTracker:9788395] Update Tracker - [Pathway:198203] PI3K/AKT activation - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783371] Update Tracker - [Pathway:198203] PI3K/AKT activation - v56:[updateContainedPathway] [UpdateTracker:9791852] Update Tracker - [Pathway:198203] PI3K/AKT activation - v25:[updateContainedRLE] [UpdateTracker:9784393] Update Tracker - [Pathway:198203] PI3K/AKT activation - v54:[updateIndirectRLE]

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[Pathway:R-HSA-187037] Signaling by NTRK1 (TRKA)

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