Reactome | PIP3 binds to RhoA and activates it

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PIP3 binds to RhoA and activates it Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:202683] Jassal, Bijay, 2007-11-08
dbId	202692
displayName	PIP3 binds to RhoA and activates it
eventOf	[Pathway:R-HSA-392451] G beta:gamma signalling through PI3Kgamma - Homo sapiens [Pathway:R-HSA-198203] PI3K/AKT activation - Homo sapiens
input	[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-194510] RHOA [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984515] Signaling networks of Rho GTPases in cell motility [LiteratureReference:2206317] Phospholipase D signaling: orchestration by PIP2 and small GTPases [LiteratureReference:8984531] The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	PIP3 binds to RhoA and activates it
orthologousEvent	[Reaction:R-MMU-202692] PIP3 binds to RhoA and activates it - Mus musculus [Reaction:R-SCE-202692] PIP3 binds to RhoA and activates it - Saccharomyces cerevisiae [Reaction:R-SPO-202692] PIP3 binds to RhoA and activates it - Schizosaccharomyces pombe [Reaction:R-CEL-202692] PIP3 binds to RhoA and activates it - Caenorhabditis elegans [Reaction:R-DME-202692] PIP3 binds to RhoA and activates it - Drosophila melanogaster [Reaction:R-GGA-202692] PIP3 binds to RhoA and activates it - Gallus gallus [Reaction:R-XTR-202692] PIP3 binds to RhoA and activates it - Xenopus tropicalis [Reaction:R-DRE-202692] PIP3 binds to RhoA and activates it - Danio rerio [Reaction:R-SSC-202692] PIP3 binds to RhoA and activates it - Sus scrofa [Reaction:R-BTA-202692] PIP3 binds to RhoA and activates it - Bos taurus [Reaction:R-CFA-202692] PIP3 binds to RhoA and activates it - Canis familiaris [Reaction:R-RNO-202692] PIP3 binds to RhoA and activates it - Rattus norvegicus
output	[Complex:R-HSA-202676] PIP3:RhoA [plasma membrane]
precedingEvent	[Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202692
summation	[Summation:202677] Several guanine exchange factors (GEFs) for the Rho family o...

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