Reactome | Synthesis of bile acids and bile salts via 24-hydroxycholesterol

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Synthesis of bile acids and bile salts via 24-hydroxycholesterol Show undefined attributes

authored	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
created	[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
dbId	193775
displayName	Synthesis of bile acids and bile salts via 24-hydroxycholesterol
edited	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
eventOf	[Pathway:R-HSA-192105] Synthesis of bile acids and bile salts - Homo sapiens
figure	[Figure:193740] /figures/24oxy_pathway.jpg
goBiologicalProcess	[GO_BiologicalProcess:20533] bile acid biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-192061] CYP46A1 24-hydroxylates CHOL - Homo sapiens [BlackBoxEvent:R-HSA-193776] Efflux of 24-hydroxycholesterol - Homo sapiens [BlackBoxEvent:R-HSA-193767] Influx of 24-hydroxycholesterol - Homo sapiens [Reaction:R-HSA-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Homo sapiens [Reaction:R-HSA-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Homo sapiens [Reaction:R-HSA-193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL - Homo sapiens [Reaction:R-HSA-193755] 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one - Homo sapiens [Reaction:R-HSA-193746] 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one - Homo sapiens [Reaction:R-HSA-193781] 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol - Homo sapiens [Reaction:R-HSA-193758] 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol - Homo sapiens [Reaction:R-HSA-193774] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens [Reaction:R-HSA-193715] 5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens [Reaction:R-HSA-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol - Homo sapiens [Reaction:R-HSA-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - Homo sapiens [Reaction:R-HSA-193780] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al - Homo sapiens [Reaction:R-HSA-193719] 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al - Homo sapiens [Reaction:R-HSA-193713] 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) - Homo sapiens [Reaction:R-HSA-193737] 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) - Homo sapiens [BlackBoxEvent:R-HSA-193722] TetraHCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-193786] 3,7,24THCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens [Reaction:R-HSA-193766] TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) - Homo sapiens [Reaction:R-HSA-193711] 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) - Homo sapiens [Reaction:R-HSA-193727] TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Homo sapiens [Reaction:R-HSA-193743] 3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Homo sapiens [BlackBoxEvent:R-HSA-193761] 25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome - Homo sapiens [BlackBoxEvent:R-HSA-193753] 3,7,24THCA-CoA is translocated from the cytosol to the peroxisome - Homo sapiens [Reaction:R-HSA-193763] Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA - Homo sapiens [Reaction:R-HSA-193736] Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:193584] Cholesterol, hydroxycholesterols, and bile acids [LiteratureReference:192080] The enzymes, regulation, and genetics of bile acid synthesis [LiteratureReference:193791] Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Synthesis of bile acids and bile salts via 24-hydroxycholesterol
orthologousEvent	[Pathway:R-MMU-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Mus musculus [Pathway:R-RNO-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Rattus norvegicus [Pathway:R-CFA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Canis familiaris [Pathway:R-BTA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Bos taurus [Pathway:R-SSC-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Sus scrofa [Pathway:R-DRE-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Danio rerio [Pathway:R-XTR-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Xenopus tropicalis [Pathway:R-GGA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Gallus gallus [Pathway:R-DME-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Drosophila melanogaster [Pathway:R-CEL-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Caenorhabditis elegans [Pathway:R-DDI-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Dictyostelium discoideum [Pathway:R-SPO-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Schizosaccharomyces pombe [Pathway:R-SCE-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Saccharomyces cerevisiae
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-193775
summation	[Summation:193730] In the body, 24-hydroxycholesterol is synthesized in the bra...
updateTrackers	[UpdateTracker:9789452] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v38:[addLiteratureReference] [UpdateTracker:9792373] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v22:[updateContainedRLE] [UpdateTracker:9792038] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v24:[updateContainedRLE] [UpdateTracker:9780025] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v64:[updateContainedRLE] [UpdateTracker:9785998] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v50:[updateContainedRLE] [UpdateTracker:9910965] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v89:[updateContainedRLE] [UpdateTracker:9791204] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v32:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-192105] Synthesis of bile acids and bile salts

(updatedInstance)

[UpdateTracker:9789452] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v38:[addLiteratureReference]
[UpdateTracker:9792373] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v22:[updateContainedRLE]
[UpdateTracker:9792038] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v24:[updateContainedRLE]
[UpdateTracker:9780025] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v64:[updateContainedRLE]
[UpdateTracker:9785998] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v50:[updateContainedRLE]
[UpdateTracker:9910965] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v89:[updateContainedRLE]
[UpdateTracker:9791204] Update Tracker - [Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - v32:[updateContainedRLE]

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