Reactome | Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one

Schema > Reaction > Entries

Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one Show undefined attributes

authored	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
catalystActivity	[CatalystActivity:192106] 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity of HSD3B7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
crossReference	[DatabaseIdentifier:12668324] RHEA:47200
dbId	193789
displayName	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one
edited	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
eventOf	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Homo sapiens
followingEvent	[Reaction:R-HSA-193746] 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one - Homo sapiens [Reaction:R-HSA-193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL - Homo sapiens
input	[SimpleEntity:R-ALL-192189] CHOL7a,24(S)DIOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:193374] Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease [LiteratureReference:193532] The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one Cholest-5-ene-3beta,7alpha,24(S)-triol + NAD+ => 4-cholesten-7alpha,24(S)-diol-3-one + NADH + H+
orthologousEvent	[Reaction:R-DME-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Drosophila melanogaster [Reaction:R-XTR-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Xenopus tropicalis [Reaction:R-DRE-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Danio rerio [Reaction:R-SSC-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Sus scrofa [Reaction:R-BTA-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Bos taurus [Reaction:R-CFA-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Canis familiaris [Reaction:R-RNO-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Rattus norvegicus [Reaction:R-MMU-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Mus musculus
output	[SimpleEntity:R-ALL-193724] 4CHOL7a,24(S)DONE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-HSA-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193789
summation	[Summation:193744] Cholest-5-ene-3beta,7alpha,24(S)-triol and NAD+ react to for...

Referrals

(hasEvent)	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(precedingEvent)	[Reaction:R-HSA-193746] 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one [Reaction:R-HSA-193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL

Cite Us!