Reactome | Synthesis of bile acids and bile salts via 24-hydroxycholesterol

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Synthesis of bile acids and bile salts via 24-hydroxycholesterol Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10994297
displayName	Synthesis of bile acids and bile salts via 24-hydroxycholesterol
eventOf	[Pathway:R-CEL-192105] Synthesis of bile acids and bile salts - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20533] bile acid biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-193755] 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one - Caenorhabditis elegans [Reaction:R-CEL-193746] 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one - Caenorhabditis elegans [Reaction:R-CEL-193781] 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol - Caenorhabditis elegans [Reaction:R-CEL-193758] 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol - Caenorhabditis elegans [Reaction:R-CEL-193766] TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) - Caenorhabditis elegans [Reaction:R-CEL-193711] 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) - Caenorhabditis elegans [Reaction:R-CEL-193727] TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Caenorhabditis elegans [Reaction:R-CEL-193743] 3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - Caenorhabditis elegans [Reaction:R-CEL-193763] Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA - Caenorhabditis elegans [Reaction:R-CEL-193736] Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of bile acids and bile salts via 24-hydroxycholesterol
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-193775
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-192105] Synthesis of bile acids and bile salts
(inferredTo)	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol

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