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Schema
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Reaction
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Entries
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol
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authored
[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
catalystActivity
[CatalystActivity:192037] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
dbId
193787
displayName
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol
edited
[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
eventOf
[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Homo sapiens
followingEvent
[Reaction:R-HSA-193780] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al - Homo sapiens
input
[SimpleEntity:R-ALL-193777] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol [mitochondrial matrix]
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
[SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
[SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:192197] Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
[LiteratureReference:193487] Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis
[LiteratureReference:193375] Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
modified
[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADP+ + H2O
orthologousEvent
[Reaction:R-SSC-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol - Sus scrofa
[Reaction:R-BTA-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol - Bos taurus
[Reaction:R-CFA-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol - Canis familiaris
[Reaction:R-RNO-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol - Rattus norvegicus
[Reaction:R-MMU-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol - Mus musculus
output
[SimpleEntity:R-ALL-193782] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol [mitochondrial matrix]
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
[SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-193774] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens
releaseDate
2007-05-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-193787
summation
[Summation:193729] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, NADPH + ...
Referrals
(hasEvent)
[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(precedingEvent)
[Reaction:R-HSA-193780] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
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